Sat, Aug-06-16, 06:33
|
|
Senior Member
Posts: 15,075
|
|
Plan: mostly milkfat
Stats: 190/152.4/154
BF:
Progress: 104%
Location: Ontario
|
|
Quote:
So if type II Diabetes is due to a lack of Insulin production, then why does lipogenesis (fat storage) seem to easily occur in type II Diabetics more than non-diabetics?
|
I'm not certain this is quite true. If you turn things around, and say that maybe obesity drives type II diabetes, then things are a little different. Once a person's body has reached its maximum potential for fat storage, less desirable fat accumulation in the liver, muscle, pancreas etc. becomes more likely. Of course the resulting hyperinsulinism is sort of a vote for additional fat storage--but the fattening effect, per unit of insulin, is actually reduced.
http://www.ncbi.nlm.nih.gov/pubmed/21343902
Quote:
Higher incremental insulin area under the curve during oral glucose tolerance test predicts less food intake and weight gain.
|
Just an abstract here. This is in Pima Indians. This seems contrary to the insulin hypothesis of obesity--a higher insulin response to a glucose tolerance test predicts less weight gain. But I don't think it's really contrary--just as I said above, insulin resistance likely means that the insulin is less effective at causing further weight gain. The authors themselves suggest that the insulin must be making the people more satiated with less food. Chyah. Try those levels of insulin if you're very insulin sensitive, good luck with the hoped for decrease in appetite then. My thinking is that since insulin resistance is high, insulin isn't just failing to lower blood glucose and free fatty acids, etc.--it's also failing to cause the hypoglycemia that would normally drive appetite with such high insulin levels in a more insulin sensitive person.
A type II diabetic on insulin therapy can certainly get fatter--but they're able to inject amounts of insulin that their pancreas can't match, at that point, blowing through the level of insulin resistance at the fat cells.
|