Active Low-Carber Forums
Atkins diet and low carb discussion provided free for information only, not as medical advice.
Home Plans Tips Recipes Tools Stories Studies Products
Active Low-Carber Forums
A sugar-free zone


Welcome to the Active Low-Carber Forums.
Support for Atkins diet, Protein Power, Neanderthin (Paleo Diet), CAD/CALP, Dr. Bernstein Diabetes Solution and any other healthy low-carb diet or plan, all are welcome in our lowcarb community. Forget starvation and fad diets -- join the healthy eating crowd! You may register by clicking here, it's free!

Go Back   Active Low-Carber Forums > Main Low-Carb Diets Forums & Support > Low-Carb Studies & Research / Media Watch > LC Research/Media
User Name
Password
FAQ Members Calendar Search Gallery My P.L.A.N. Survey


Reply
 
Thread Tools Display Modes
  #1   ^
Old Sat, Aug-27-22, 02:58
Demi's Avatar
Demi Demi is offline
Posts: 26,731
 
Plan: Muscle Centric
Stats: 238/153/160 Female 5'10"
BF:
Progress: 109%
Location: UK
Default Some artificial sweeteners can raise your blood sugar

Quote:
Some artificial sweeteners can raise your blood sugar

Two artificial sweeteners, saccharin and sucralose, may impede the body’s ability to regulate blood sugar levels after eating, potentially due to associated changes in the microbiome


Two artificial sweeteners, saccharin and sucralose, have been found to increase blood sugar levels despite being thought not to. This may be related to changes the sweeteners induce in gut microbes.

These sweeteners are a sugar alternative for people with metabolic conditions such as diabetes or for those looking to lose weight, as they are more than 200 times sweeter than sugar and contain few to zero calories.

Jotham Suez at Johns Hopkins University in Maryland and his colleagues tested the effects of four sugar substitutes on blood sugar in 120 adults in Israel without underlying health conditions. The participants reported that they did not consume low-calorie sweeteners during the six months prior to the study.


They were then divided into six groups and supplied with 1-gram packets of sweeteners. For two weeks, participants in four of these groups consumed two packets three times a day of either aspartame, sucralose, saccharin or stevia dissolved in water. The sweetener packets all contained at least 96 per cent glucose, as the sweeteners are so potent that only a small amount is needed –glucose is used as a bulking agent so the sweeteners can be packaged. The total daily dose of each sweetener was below the accepted daily intake determined by the US Food and Drug Administration. A fifth group consumed equivalent amounts of glucose powder over the same period and the last group had no supplement.

All participants wore continuous blood sugar monitors throughout the study and for a week before and afterwards. At nine points in the study, the participants completed a glucose tolerance test, which measures how effectively the body controls blood sugar levels after consuming glucose.

On average, the researchers found that people who consumed saccharin and sucralose had significant spikes in blood sugar after the glucose tolerance tests. Blood sugar remained stable or even decreased slightly in all of the other groups, even those consuming daily glucose – suggesting it is not the glucose in the sweetener packets that is raising blood sugar levels, says Suez.

While an increase in blood sugar is expected after eating glucose, people with an impaired blood sugar response have a greater increase in glucose levels and these levels stay elevated for longer, he says.

Suez and his team also analysed daily stool and saliva samples from the participants and found that all four sweeteners significantly altered the abundance, activity and types of bacteria in the gut and mouth. They also collected weekly blood samples and found corresponding changes in metabolites, or molecules that are by-products of digestion.

A few of the blood metabolite changes seen in the saccharin and sucralose groups are also seen in people with diabetes or vascular diseases. Some were in pathways known to play a role in the breakdown of sugars.

The researchers also transplanted stool samples from people eating saccharine, sucralose, glucose and no supplement into the digestive tracts of mice, and found that transplants from the saccharine and sucralose groups resulted in an increase in the mouse’s blood sugar after a meal.

This suggests it was the microbial changes that led to this outcome, says Suez. “The sweeteners themselves do not raise blood glucose,” he says, but seem to impair the body’s ability to manage glucose levels after eating through mechanisms mediated by the microbiome.

However, the health effects of these microbial and metabolic changes are still unknown. Suez hopes future trials will help untangle these relationships.

Alice Lichtenstein at Tufts University in Massachusetts says longer studies are needed to determine whether the observed elevation in blood sugar is enough to cause health problems.

“We are definitely not saying switch to [sugar-sweetened beverages], which have been beyond a doubt associated with metabolic disease,” Suez says. “I would say if people can switch to water, that’s always the best option.”

Journal reference: Cell, DOI: 10.1016/j.cell.2022.07.016

https://www.newscientist.com/articl...ur-blood-sugar/
Reply With Quote
Sponsored Links
  #2   ^
Old Sat, Aug-27-22, 05:50
Ms Arielle's Avatar
Ms Arielle Ms Arielle is offline
Senior Member
Posts: 19,218
 
Plan: atkins, carnivore 2023
Stats: 200/211/163 Female 5'8"
BF:
Progress: -30%
Location: Massachusetts
Default

Thanks for posting. Sucralose is my daily go to. Time to eliminate.
Reply With Quote
  #3   ^
Old Sat, Aug-27-22, 07:08
WereBear's Avatar
WereBear WereBear is offline
Senior Member
Posts: 14,675
 
Plan: EpiPaleo/Primal/LowOx
Stats: 220/130/150 Female 67
BF:
Progress: 129%
Location: USA
Default

Likewise: i was very low on any sweeteners but reading the ingredients of my favorite chocolate protein shake powder revealed three suspects: maltodextrose, sucralose, and acesulfame potassium.

All in low amounts: one of the reasons it's my favorite is that it is not over-sweetened, and I noted they had used the tactic of synergy where three small amounts of compatible sweetener added up to less than using only one kind. Also, I do not get the intestinal reactions from this brand that I get from, say, more than a few sugar alcohol candies

Still got me thinking about switching over to unflavored and adding my own cocoa. Fruit is lately my sweetener, and not in jam sized portions, either.

In fact, we got a peach each from our neighbor, who has a friend near a fabulous farmer's market. We told her we'd like two nice fresh ones more than a peach pie this year. I couldn't finish mine! I got halfway through and was satisfied.

So my sugar sensitivity is nice and low. Still, I think we all need to keep this in mind for emergency food. It's not just road trips: I was on five months of bed rest and a good meal that took so little effort, in making, consuming, and cleaning up after, is now one of my must-haves.

And Bob the musician mentioned the unflavored kind he uses. I'd bookmarked it. Time to use the spreadsheet to see that this might save me money, too.
Reply With Quote
  #4   ^
Old Sat, Aug-27-22, 09:39
Nancy LC's Avatar
Nancy LC Nancy LC is offline
Experimenter
Posts: 25,863
 
Plan: DDF
Stats: 202/185.4/179 Female 67
BF:
Progress: 72%
Location: San Diego, CA
Default

So, some details that most news services are kind of hiding are that the spikes in blood glucose came after consuming glucose (a sugar). Which this isn't really new news. This was observed in other studies.

Only a few sweeteners were tested. And this article doesn't mention the stevia trial which actually lowered blood sugar response.

Erythritol, allulose, stevia are my favorite sweeteners and they're all found naturally in fruits, veggies, and birch.

Do people even use saccharin still? Sad to see sucralose is an issue. Also, think some cancer studies are point to acesulfame and sucralose as possibly carcinogenic. But the details are sketchy in my head.

I think allulose is about as close in taste and cooking properties as you can get to sugar. It works really well with chocolate! Doesn't have any annoying fillers. Erythritol + allulose is a very good combo.
Reply With Quote
  #5   ^
Old Sat, Aug-27-22, 20:21
deirdra's Avatar
deirdra deirdra is offline
Senior Member
Posts: 4,328
 
Plan: vLC/GF,CF,SF
Stats: 197/136/150 Female 66 inches
BF:
Progress: 130%
Location: Alberta
Default

It says "The sweetener packets all contained at least 96 per cent glucose, as the sweeteners are so potent that only a small amount is needed – glucose is used as a bulking agent so the sweeteners can be packaged."

So is it the 4% AS or the 96% glucose that is raising BG ??? I did read the part that tried to explain it away, but why would you even add such a confounding ingredient in such a study? Why not make up liquid forms of each sweetener with plain water? The glucose could be activating receptors causing the AS to behave differently in the body.

The sweeteners can affect the gut biome, but so does glucose. That's why I limit myself to minimal amounts of stevia (a few drops/day) and erythritol (~1 tsp/wk).

Last edited by deirdra : Sat, Aug-27-22 at 20:34.
Reply With Quote
  #6   ^
Old Sun, Aug-28-22, 07:08
WereBear's Avatar
WereBear WereBear is offline
Senior Member
Posts: 14,675
 
Plan: EpiPaleo/Primal/LowOx
Stats: 220/130/150 Female 67
BF:
Progress: 129%
Location: USA
Default

Quote:
Originally Posted by deirdra
It says "The sweetener packets all contained at least 96 per cent glucose, as the sweeteners are so potent that only a small amount is needed – glucose is used as a bulking agent so the sweeteners can be packaged."

So is it the 4% AS or the 96% glucose that is raising BG ???


Quote:
Originally Posted by Nancy LC
I think allulose is about as close in taste and cooking properties as you can get to sugar. It works really well with chocolate! Doesn't have any annoying fillers. Erythritol + allulose is a very good combo.


Exactly. Recently news broke the Alzheimer's treatment has been going in the WRONG direction for 20 years, and okay, that's science, but I can't help but wonder how much of that is not admitting how much of it might be caused by statins?

I don't mind real science. I do mind being conned.

Which is why I keep my sweeteners rare and safe

Because it's not just the numbers, it's the kind of carbs: at least with me. 10 grams of carbs in raspberries added to a smoothie is not handled the same as 10 grams of carbs in a small portion of an average protein bar. Real food still rules.

I think what gets people in trouble is the concept of relentlessly substituting when their diet was too unbalanced already. Too much flour/sugar substitute likely has less bad effects, but still not good ones.

I am finding high protein/low sugar "keto" treats are doing for DH what they did for me, a helpful way to make the transition and have a quick meal option. Our functional doctor prefers to white-knuckle temptation.

But that gets old, I tell him
Reply With Quote
  #7   ^
Old Sun, Aug-28-22, 08:11
Calianna's Avatar
Calianna Calianna is online now
Senior Member
Posts: 1,891
 
Plan: Atkins-ish (hypoglycemia)
Stats: 000/000/000 Female 63
BF:
Progress: 50%
Default

If they didn't do the experiment repeatedly, switching the ones who had sucralose or saccharin to the other sweeteners, how do they know for sure that it wasn't just that the ones who happened to get sucralose and saccharin happened have a reaction to the 96+% glucose packets?

Also, even though all non-nutritive sweeteners are extremely concentrated, when they say the packets contained "at least 96% glucose" that means some of the sweeteners are so concentrated that they had to have an even higher percentage of glucose in them. The least concentrated of those sweeteners were 4% of the packet.

Pure sucralose is 600 times sweeter than sugar, pure saccharin is somewhere between 500-600 times sweeter than sugar.

Aspartame is about 1/3 as concentrated at about 200 times sweeter than sugar, and Stevia is also in the low range, from 100-300 times sweeter than sugar (depending on the exact form of stevia - Stevioside, Steviol glycoside, Rebaudioside A, or Steviol)

Someone who is better at math than I am can certainly figure out how much more of the packet needed to be glucose to even out the sweetening power, but since sucralose and saccharin are 2-6 times as sweet as aspartame and stevia, the packets containing those would have needed to be more than 99% glucose to keep the sweetening power of the saccharin or sucralose from becoming overwhelming.

Just a thought though - Even though they didn't get the same results from the group using the pure glucose packets, I wonder how much of the results could have been due to the higher concentration of glucose in the sucralose and aspertame products stimulating a blood sugar response (as well as gut changes) when in combination with those two extremely concentrated sweeteners. Even though the glucose in this experiment is a very small amount, it may not be nearly as unimportant as they would like to think.
Reply With Quote
  #8   ^
Old Sun, Aug-28-22, 09:36
Calianna's Avatar
Calianna Calianna is online now
Senior Member
Posts: 1,891
 
Plan: Atkins-ish (hypoglycemia)
Stats: 000/000/000 Female 63
BF:
Progress: 50%
Default

Quote:
Originally Posted by WereBear
Exactly. Recently news broke the Alzheimer's treatment has been going in the WRONG direction for 20 years, and okay, that's science, but I can't help but wonder how much of that is not admitting how much of it might be caused by statins?


My mother never took statins, but had Alzheimers.



On the other hand, she had always eaten a very low fat diet, and ate a LOT of carbs (which increased significantly when her dr insisted that she needed to eat less meat).



Towards the last year or so of her life, she had increased her use of sweets (particularly jelly and jam on her breads) significantly. When she was young, she had always been careful to use only a tiny smear of jelly and jam on breads.
Quote:
I don't mind real science. I do mind being conned.


Which is why I keep my sweeteners rare and safe

Because it's not just the numbers, it's the kind of carbs: at least with me. 10 grams of carbs in raspberries added to a smoothie is not handled the same as 10 grams of carbs in a small portion of an average protein bar. Real food still rules.

I think what gets people in trouble is the concept of relentlessly substituting when their diet was too unbalanced already. Too much flour/sugar substitute likely has less bad effects, but still not good ones.

I am finding high protein/low sugar "keto" treats are doing for DH what they did for me, a helpful way to make the transition and have a quick meal option. Our functional doctor prefers to white-knuckle temptation.

But that gets old, I tell him



When I made the switch back to a LC diet, I gave up the carbs in stages, a little at a time.



At that point in my life, I just couldn't see myself being successful at giving up everything at once.


I did use some Atkins bars (which back in those days had little or no sugar alcohols in them), which helped with the transition.



I also made some protein bars from things like whey protein and almond butter, as well as treats like LC cheesecake.



Over the years, I came to the realization that I have little to no portion control using those ingredients, so I rarely use them now, or try to make them in such small quantities that portion control is not a problem.



I do have some "treats" I still make using artificial sweeteners, but not many, and usually only the ones that I'm not tempted to go back and make/eat more and more and more.
Reply With Quote
  #9   ^
Old Mon, Aug-29-22, 09:18
WereBear's Avatar
WereBear WereBear is offline
Senior Member
Posts: 14,675
 
Plan: EpiPaleo/Primal/LowOx
Stats: 220/130/150 Female 67
BF:
Progress: 129%
Location: USA
Default

Quote:
Originally Posted by Calianna
My mother never took statins, but had Alzheimers.

...

On the other hand, she had always eaten a very low fat diet, and ate a LOT of carbs (which increased significantly when her dr insisted that she needed to eat less meat).


Amy Berger wrote her book about how high carb eating contributes to Alzheimers, as does statins. Because the problem predated statins, of course, and there are many ways dementia can take place and damage the brain, sadly.

Part of them calling this syndrome Diabetes III is how the insulin resistance keeps fuel from reaching the cells, and they can't function. This might be what goes on with Alzheimer patients craving sweets.

Maybe that is what the brain is signaling, and we aren't listening.
Reply With Quote
  #10   ^
Old Mon, Aug-29-22, 11:13
Nancy LC's Avatar
Nancy LC Nancy LC is offline
Experimenter
Posts: 25,863
 
Plan: DDF
Stats: 202/185.4/179 Female 67
BF:
Progress: 72%
Location: San Diego, CA
Default

My diet has continuously improved, but as much due to DDF as to Keto or Atkins, maybe more.
Reply With Quote
  #11   ^
Old Tue, Aug-30-22, 07:33
khrussva's Avatar
khrussva khrussva is offline
Say NO to Diabetes!
Posts: 8,671
 
Plan: My own - < 30 net carbs
Stats: 440/228/210 Male 5' 11"
BF:Energy Unleashed
Progress: 92%
Location: Central Virginia - USA
Default

Quote:
Originally Posted by Ms Arielle
Thanks for posting. Sucralose is my daily go to. Time to eliminate.

Ditto. That was pretty compelling evidence that it's time to give up my Mio and other SF products that contain sucralose.
Reply With Quote
  #12   ^
Old Tue, Aug-30-22, 12:01
Ms Arielle's Avatar
Ms Arielle Ms Arielle is offline
Senior Member
Posts: 19,218
 
Plan: atkins, carnivore 2023
Stats: 200/211/163 Female 5'8"
BF:
Progress: -30%
Location: Massachusetts
Default

Quote:
Originally Posted by khrussva
Ditto. That was pretty compelling evidence that it's time to give up my Mio and other SF products that contain sucralose.



I've made the jump to ice water and seltzer.

Replacing sucralose in blueberries n cream is more challenging. Just cutting out may be only answer.

Back to munching frozen berries!!
Reply With Quote
  #13   ^
Old Tue, Aug-30-22, 13:36
Nancy LC's Avatar
Nancy LC Nancy LC is offline
Experimenter
Posts: 25,863
 
Plan: DDF
Stats: 202/185.4/179 Female 67
BF:
Progress: 72%
Location: San Diego, CA
Default

Trader Joe's has a less expensive stevia, allulose blend. But I really like confectioner's erythritol on frozen berries. Also allulose. I should try to powder some allulose in a coffee grinder. Sadly allulose is pretty expensive still.
Reply With Quote
  #14   ^
Old Tue, Aug-30-22, 16:11
Ms Arielle's Avatar
Ms Arielle Ms Arielle is offline
Senior Member
Posts: 19,218
 
Plan: atkins, carnivore 2023
Stats: 200/211/163 Female 5'8"
BF:
Progress: -30%
Location: Massachusetts
Default

Thanks Nancy!! Good to know. Will check out Trader Joe's.
Reply With Quote
  #15   ^
Old Wed, Sep-07-22, 08:47
Calianna's Avatar
Calianna Calianna is online now
Senior Member
Posts: 1,891
 
Plan: Atkins-ish (hypoglycemia)
Stats: 000/000/000 Female 63
BF:
Progress: 50%
Default

Quote:
Originally Posted by Calianna
If they didn't do the experiment repeatedly, switching the ones who had sucralose or saccharin to the other sweeteners, how do they know for sure that it wasn't just that the ones who happened to get sucralose and saccharin happened have a reaction to the 96+% glucose packets?

Also, even though all non-nutritive sweeteners are extremely concentrated, when they say the packets contained "at least 96% glucose" that means some of the sweeteners are so concentrated that they had to have an even higher percentage of glucose in them. The least concentrated of those sweeteners were 4% of the packet.

Pure sucralose is 600 times sweeter than sugar, pure saccharin is somewhere between 500-600 times sweeter than sugar.

Aspartame is about 1/3 as concentrated at about 200 times sweeter than sugar, and Stevia is also in the low range, from 100-300 times sweeter than sugar (depending on the exact form of stevia - Stevioside, Steviol glycoside, Rebaudioside A, or Steviol)

Someone who is better at math than I am can certainly figure out how much more of the packet needed to be glucose to even out the sweetening power, but since sucralose and saccharin are 2-6 times as sweet as aspartame and stevia, the packets containing those would have needed to be more than 99% glucose to keep the sweetening power of the saccharin or sucralose from becoming overwhelming.

Just a thought though - Even though they didn't get the same results from the group using the pure glucose packets, I wonder how much of the results could have been due to the higher concentration of glucose in the sucralose and aspertame products stimulating a blood sugar response (as well as gut changes) when in combination with those two extremely concentrated sweeteners. Even though the glucose in this experiment is a very small amount, it may not be nearly as unimportant as they would like to think.



After thinking more about it for a while, I'm going to disagree with myself a bit. I don't think the glucose in the packets was a factor, since each packet only had 1 g total weight. Even the sucralose and saccharin packets had no more glucose in them than the packets that were 100% glucose.



Other thoughts:


Since this study was done on those not using any kind of artificial sweeteners in the previous 6 months, my assumption is that they were all eating a fairly standard high carb diet.



That makes me wonder if what's happening is that there's some chemical component/combination in the sucralose and saccharin (not present in the stevia and aspartame) that stimulates the release of excessive amounts of glycogen.



If one assumes they were all eating a standard high carb diet, my question is what happens if they're eating a Keto/LC diet, since there would be very minimal glucose entering the system, and very minimal glycogen storage to draw upon?



Which makes me wonder - if someone new to LC is still in induction, would using sucralose or saccharin help them use up those glycogen stores more quickly?



In the absence of more than very minimal dietary carbs, and once the glycogen stores are used up, how would sucralose or saccharin be able to raise blood sugar at all? Where could the glucose possibly come from that would cause sucralose or saccharin to raise blood sugar?



Testing only those 4 sweeteners also raise the question of in the absence of anything else in the diet that raises blood sugar, what kind of blood glucose response would there be with other types of sweeteners: allulose, Erythritol, xylitol, other sugar alcohols, oligofructose, ace K, monk fruit - I've probably forgotten quite a few of the ones avaiable.
Reply With Quote
Reply


Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

vB code is On
Smilies are On
[IMG] code is On
HTML code is Off



All times are GMT -6. The time now is 08:08.


Copyright © 2000-2024 Active Low-Carber Forums @ forum.lowcarber.org
Powered by: vBulletin, Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.