Do what I'm doing and experiment! You've got a glucose meter right? The dose I was taking was very large, like 8 times your dose.

Ok, today's FBG was 105 but I ate very oddly yesterday. I kind of stuffed myself on things I don't normally eat... not high carb, just not normal food for me, cheese, nuts, stuff like that. It's my birthday week and I'm celebrating. However, I went a bit overboard last night, to the point I felt sick during the night. Bleh!

Too much fat can make you temporarily insulin resistant.

Really? How does that work?

The simplistic answer is that cells full of triglycerides are not keen on taking up glucose:

http://www.liebertonline.com/doi/ab...9/met.2005.3.14

Muscle cells or fat cells? Seems like fat cells are always full of triglycerides aren't they? It is kind of their job. And I thought fat didn't cause any insulin response, so how can it cause insulin resistance?

Ok, well, I can only see the first page of the study and all it says (that I can understand) is that insulin resistance happens because the cells are too full of glucose to store any more.

Dr. Volek is one of the authors and he's usually very pro-low carb and a lot of his studies are at:
http://nutritionandmetabolism.com

I'm looking for other studies that I can actually read.

It is my understanding that in the presence of high fat levels, the liver becomes resistant as well as the muscle cells. When you are in fat-burning mode, your cells are not taking up glucose.

Oh, so you're saying that if you're burning ketones for energy, as opposed to glucose, then you can't store glucose? Seems like that would lead to a crisis pretty quickly since your body always needs to have about 1 tsp of glucose available. If you couldn't store it, you'd run out quickly and start cannibalizing your own muscle tissues to make more which would lead to rapid starvation. And that just doesn't happen on LC. We still are able to store glycogen in our muscles and liver, even when in very deep ketosis.

We probably do lose insulin receptors on some cells simply because we don't need as many due to lower insulin levels. I think that's probably why there is a recommendation to carb up a few days before having a GTT test done. I know Dr. Eades has talked about needing a different set of enzymes on a high carb diet and it takes awhile to switch from one set of enzymes to the other.

I guess you could call that insulin resistance because if you got a big surge of glucose your body wouldn't be able to deal with it all that well. But I think it's probably a different sort of insulin resistance than you'd get on a high carb diet.

Well, I'm open to learning more if you find stuff!

No, I'm saying you can't store it as well. We don't store nearly the amount of glycogen in our livers when we are in ketosis than we we're not. Just think water weight gain and loss.

How do you explain "glucose intolerance" that Eades talks about?

Cannibalizing tissue occurs in the absence of insulin. That is what DKA is.

Oh that's true. I forgot about that huge amount of peeing that happens.
I don't remember that, I'll have to reread. Is it in his blog?

Yes, it is a caution about how low carbing can affect a GTT. I don't buy his explanation about enzymes unless he is talking about insulin.

Google on carbohydrate metabolizing enzymes, quite a lot of stuff came up.

Glucose doesn't need to be metabolized. It doesn't explain why someone would do poorly on a GTT.

If you way overdid it on protein it will convert into carb very slowly overnight and raise your FBG.

That's very true. I have a harder time covering the conversion of protein with insulin than I do carbs because I can predict the action of carbs. Protein can take 6 or 7 hours to convert.