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  #1   ^
Old Wed, Jan-17-24, 12:06
Ms Arielle's Avatar
Ms Arielle Ms Arielle is offline
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Plan: atkins, carnivore 2023
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Default Its BMI not saturated fats in low carb diets

https://youtu.be/FcUUqGJBXFM?si=4VmVtWH52Rt35nwc

A new meta study looking at LDL level, bmi correlated to LDL. Inverse on a low carb diet.

Maybe someone can summarize this video into text.
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  #2   ^
Old Wed, Jan-17-24, 13:31
doreen T's Avatar
doreen T doreen T is offline
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Plan: LC paleo
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Here's the actual study, published today in American Journal of Clinical Nutrition ..

Increased LDL-cholesterol on a low-carbohydrate diet in adults with normal but not high body weight: a meta-analysis


Quote:
Abstract

Background
LDL-cholesterol (LDL-C) change with consumption of a low-carbohydrate diet (LCD) is highly variable. Identifying the source of this heterogeneity could guide clinical decision-making.

Objective
To evaluate LDL-C change in randomized controlled trials (RCTs) involving LCDs, with a focus on body mass index (BMI).

Design
Three electronic indexes (Pubmed, EBSCO, Scielo) were searched for studies between 1 January 2003 and 20 December 2022. Two independent reviewers identified RCTs involving adults consuming <130 g/day carbohydrate and reporting BMI and LDL-C change or equivalent data. Two investigators extracted relevant data which were validated by other investigators. Data were analyzed using a random-effects model and contrasted with results of pooled individual participant data (IPD).

Results
Forty-one trials with 1379 participants and a mean intervention duration of 19.4 weeks were included. In a meta-regression accounting for 51.4% of the observed heterogeneity on LCDs, mean baseline BMI had a strong inverse association with LDL-C change (β=-2.5 mg/dL per BMI unit, CI95% = -3.7 to -1.4), whereas saturated fat amount was not significantly associated with LDL-C change. For trials with mean baseline BMI <25 kg/m2, LDL-C increased by 41 mg/dL, (CI95% = 19.6 to 63.3) on the LCD. By contrast, for trials with mean BMI 25 to <35 kg/m2, LDL-C did not change; and for trials with mean BMI ≥35 kg/m2, LDL-C decreased by 7 mg/dL (CI95% = -12.1 to -1.3). Using IPD, the relationship between BMI and LDL-C change was not observed on higher-carbohydrate diets.

Conclusions
A substantial increase in LDL-C is likely for individuals with low but not high BMI with consumption of a LCD, findings that may help guide individualized nutritional management of cardiovascular risk. As carbohydrate restriction tends to improve other lipid and non-lipid risk factors, the clinical significance of isolated LDL-C elevation in this context warrants investigation.

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  #3   ^
Old Thu, Jan-18-24, 03:41
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WereBear WereBear is online now
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My conclusion is that LDL-C is not dangerous once the person lowers their BMI. Am I missing something? she asked sarcastically.

Yes, it merits investigation. It's trying to reshape how Western Medicine views cholesterol. Which keeps getting NOT supported in actual research.

When something is this obscured and obtuse maybe it's on purpose.
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  #4   ^
Old Thu, Jan-18-24, 11:01
Ms Arielle's Avatar
Ms Arielle Ms Arielle is offline
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Plan: atkins, carnivore 2023
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Yes, its frustrating.

We need to keep proving a low carb diet has far more health benefits than living an obese SAD life.

This study is one more proof to support low carb is safe.

( thanks Doreen for finding the study and posting. ,)
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  #5   ^
Old Sun, Jan-21-24, 11:22
dan_rose dan_rose is offline
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Dr Eades Arrow has some notes on this paper:
https://michaeleades.substack.com/p/the-arrow-159
(Search for 'Hyper' to skip to the relevant section).
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  #6   ^
Old Sat, Jan-27-24, 01:40
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Demi Demi is offline
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Plan: Muscle Centric
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Default Increased LDL-cholesterol on a low-carb diet in adults with normal body weight

Quote:
Increased LDL-cholesterol on a low-carbohydrate diet in adults with normal but not high body weight: a meta-analysis

Abstract

Background

LDL-cholesterol (LDL-C) change with consumption of a low-carbohydrate diet (LCD) is highly variable. Identifying the source of this heterogeneity could guide clinical decision-making.

Objective
To evaluate LDL-C change in randomized controlled trials (RCTs) involving LCDs, with a focus on body mass index (BMI).

Design
Three electronic indexes (Pubmed, EBSCO, Scielo) were searched for studies between 1 January 2003 and 20 December 2022. Two independent reviewers identified RCTs involving adults consuming <130 g/day carbohydrate and reporting BMI and LDL-C change or equivalent data. Two investigators extracted relevant data which were validated by other investigators. Data were analyzed using a random-effects model and contrasted with results of pooled individual participant data (IPD).

Results
Forty-one trials with 1379 participants and a mean intervention duration of 19.4 weeks were included. In a meta-regression accounting for 51.4% of the observed heterogeneity on LCDs, mean baseline BMI had a strong inverse association with LDL-C change (β=-2.5 mg/dL per BMI unit, CI95% = -3.7 to -1.4), whereas saturated fat amount was not significantly associated with LDL-C change. For trials with mean baseline BMI <25 kg/m2, LDL-C increased by 41 mg/dL, (CI95% = 19.6 to 63.3) on the LCD. By contrast, for trials with mean BMI 25 to <35 kg/m2, LDL-C did not change; and for trials with mean BMI ≥35 kg/m2, LDL-C decreased by 7 mg/dL (CI95% = -12.1 to -1.3). Using IPD, the relationship between BMI and LDL-C change was not observed on higher-carbohydrate diets.

Conclusions
A substantial increase in LDL-C is likely for individuals with low but not high BMI with consumption of a LCD, findings that may help guide individualized nutritional management of cardiovascular risk. As carbohydrate restriction tends to improve other lipid and non-lipid risk factors, the clinical significance of isolated LDL-C elevation in this context warrants investigation.

Read the sttudy in full https://www.sciencedirect.com/scien...via%3Dihub]here.
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  #7   ^
Old Sat, Jan-27-24, 10:26
JEY100's Avatar
JEY100 JEY100 is online now
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This study has been getting picked apart on Twitter, and one thing (of many) that drives me crazy about X is having to analyze a scientific study in a 13 part thread dense with charts

Keven Hall starts his this morning, "A paper by ~AdrianSotoMota ~nicknorwitz ~davidludwigmd et al. reanalyzed data from our previous study, claiming to have invalidated our primary findings, & concluding that our data support the carbohydrate-insulin model (CIM) of obesity.
Our response: Despite generating lots of noise, their reanalysis never addressed our study’s primary outcome: differences in energy intake when the same people ate low carb (LC) vs low fat (LF) diets. Our result was valid & there was no significant effect of diet order.
Instead, they attempted to analyze whether the group of participants assigned to the LC followed by the LF diet had different outcomes compared to those assigned to the reverse order. That’s a separate but interesting topic. Unfortunately, their reanalysis had several fatal flaws….and then he lists them in excruciating detail, shredding the authors. ….

Overall, the reanalysis paper exhibited poor scholarship by failing to engage with our prior work, suggested their analysis was more novel than it was, ignored the within-participant study design, failed to disclose the possibility of bias, & committed many statistical errors.
……
In summary, the fatally flawed reanalysis by ~AdrianSotoMota ~nicknorwitz ~davidludwigmd et al attempted to resurrect the CIM by following the adage "if you torture data long enough, it will confess to anything". In this case, data torture led to a false confession of CIM support.

There's more, but you get his point. I stopped believing in the CIM a few years ago so I ignored this study, but response is worth sharing.

Last edited by JEY100 : Sat, Jan-27-24 at 10:46.
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  #8   ^
Old Mon, Jan-29-24, 17:51
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GRB5111 GRB5111 is offline
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Plan: Very LC, Higher Protein
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Default

Any time a finding challenges one's belief system, there are repercussions that come with strong claims about being wrong. Those firmly in one camp vs another want the findings to be wrong. No one wants to be wrong. Those who have done earlier studies that are found lacking will argue and insult the new study, thus casting suspicion on the unwillingness to carry out the scientific method with productive dialog purely for learning new information. This is clear in this situation. What I know is that diet wars are unproductive and cause confusion. This is no different than the arguments among vegans, vegetarians, omnivores of many different dietary stripes and persuasions, low carb, ketogenic, carnivore, Paleo, optimising nutrition, satiety per calorie (SPC), CIM, P:E, and on and on and on. There are divisions being established on this forum, where only the naive would think we would agree on everything dietary. Why? Because no one has the answer for a single, perfect human diet that applies equally to everyone guaranteeing optimum health. Anyone who claims this and can prove it should be recognized as the "missing" expert in all things dietary. Until then, I'll keep reading and continually learning to ensure I am eating healthy foods and maintaining a healthy lifestyle.
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  #9   ^
Old Fri, Feb-02-24, 16:43
JEY100's Avatar
JEY100 JEY100 is online now
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Plan: P:E/DDF
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BF:45%/28%/25%
Progress: 134%
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Default

A blast from the past Denise Minger (author of Death by Food Pyramid) writes:

Quote:
The low carb community shot itself in the foot by attaching its validity to a speculative model/mechanism and centering itself as the “good guy” in a moralized version of nutritional history.

It’s now in the unfortunate position of having to defend that model order to uphold its own narrative.

If low carb really has the metabolic advantages proposed by the Carbohydrate-Insulin Model, there would be no need to torture data, bully scientists, dismiss studies under wild conspiratorial speculation, hold research to bizarre double standards of criticism based on whether it supports or invalidates a low-carb advantage, or position legitimate scientists as “enemies” simply because they produced data that contradicts the CIM.

The evidence would show up readily, leave echoes in both observational and clinical studies, and not be such a wild goose chase to find.

The worst part is, low carb probably really is great for certain people/contexts, but the fixation on the Carbohydrate-Insulin Model needing to be right keeps the community focused on fighting its (entirely imaginary) opponents rather than actually figuring out what’s true.

Opponents who themselves don’t even see themselves as opponents because they’re actually just interested in following the data and adapting their theories accordingly. It’s so weird watching a war in which only one side sees itself as fighting

This vaguetweet is in reference to ~KevinH_PhD getting mobbed by Low Carb True Believers for the cardinal sin of conducting a study that did not support the carbohydrate-insulin model

Dr Eenfeldt retweeted Denise's post with his comment: "Low carb works great for many (science confirms it), but this is unfortunately too true"

Like Dr Eenfeldt, Dr Naiman and Marty Kendall, more low carb influencers now understand that the Carbohydrate-Insulin model is incomplete, and your Energy Toxicity needs to be addressed. Six good articles on Insulin at this post:
https://forum.lowcarber.org/showpos...4&postcount=287

Last edited by JEY100 : Sat, Feb-03-24 at 05:13.
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