Hmmm... you must not know me well. I'm probably the worst skeptic on the forum. I annoy people all the time with my skepticism.
I decide to take the supplements on evidence from studies and continue taking them on faith of the science that convinced me in the first place.
I don't possess a lab so I can't evaluate things that are happening to me that I can't observe myself, so I trust the science was right.
Every now and then I'll jump on someone else's bandwagon but usually jump off quickly if I don't see noticeable results.
But I must say, things happen subtlety with me. I have a lot of aches and pains that have disappeared. But they did so slowly so I can't really attribute them to any one thing. Although I suspect raising my D3 levels to 60 ng/ml was probably a biggie and I suspect that taking fish oil (switch to higher dose liquid form) might be another good one.
Lately I've been getting little sensations like a bug is biting me, and I think that might be neuropathy from B12 depletion. I haven't been very good about supplementing my B lately. It seems odd I would be B12 deficient given how much meat I eat, but perhaps I don't absorb it well.
Anyway, my point is that if you're looking for
practical benefits from supplements as your title suggests, it sounds like you're looking for supplements that people KNOW made them feel something and I doubt that supplements are all that obvious most of the time, unless maybe you had a severe deficiency or something. And it's hard to untangle that from a placebo effect anyway.