The drug against glucose reabsorption in this context is interesting. In the context of a higher carb diet, the use of this drug for diabetics doesn't make sense to me. The possibility of infection for one. On a ketogenic diet thought, while small increases in glucose in the urine would make it easier to maintain ketosis, the absolute glucose numbers might be small enough that that sort of risk isn't all that high. Glucose numbers are so tight on a very restrictive medical version of a keto diet that tiny bits of glucose lost in the urine could make a big difference. Not worth doing so somebody can eat some marshmallows, maybe worth it if somebody needs to be on a really tight program if it allows them an extra couple ounces of cheese.

As much as I would also like this to be true, I heard a new podcast episode this morning that inserts the caveat... ~JustSaysInMice.

https://www.bbc.co.uk/programmes/p07kv9ns

When I posted about the sugar going straight for the cancer, I didn't want to imply that sugar causes cancer. It might, and it might not.

But what seems obvious to me is that if you have cancer, eating sugar is like pouring gasoline on the fire.

Bob

That's my view as well. The mechanism that causes cancer is complex, but the fact that cancer requires glucose to survive and spread is something many should understand. I, as well, feel that a very low carb/ keto approach may have preventive value along with following a healthy lifestyle in other areas. I know it has preventive and corrective value for many other health issues due to direct experience, so it's not hard to extend the potential value to cancer as well.

When I realized the sugar-cancer connection, the issue became how low can blood sugar go. Low carbing certainly drops the blood glucose sigificantly but the minimal level required to maintain stasis kept me looking for a more effective method.

Led me to fasting. An area honestly I dismissed on many levels. But I am a convert. Is fasting the killer of cancer?? Cancer is complex, and research is still inadequate. But given the current thinking, and current studies, fasting maybe the key. Seems that fasting does two things: reduce the blood sugars to minimal levels, and body does repairs etc, likr autophagy. Hope Im using autophagy correctly. Still learning.

Im banking on the dual effects of fasting to kill/ control cancer cells.

The idea of paying money to eat sugar and then paying more money for a drug to remove it from your system must sound wonderful to some people, but it is cheaper to not eat it in the first place.

If you are making BIG DOUGH from human misery, it's different!

I doubt the mice are eating sugar. Not that they have to pay for it anyways. It's harder to get a mouse into ketosis, some studies have fat intake as high as 95 percent of calories, that doesn't leave room for much protein--the drug likely allows a more liberal protein intake while helping keep ketones higher. Which sounds plausibly beneficial.

I know a type 1 diabetic. She played with her insulin and ate a lot of sugar (she made the best pecan pie in the world). Eventually she needed a kidney and pancreas transplant and is almost blind.

My father had type 2 and when his insulin resistance was so bad, he was prescribed a drug that increased his insulin secretion to process the sugar he was eating. At that time it was only a couple of donuts with his brother at a coffee shop per day. The insulin burnt out the blood vessels in his heard and kidneys.

Sugar burns blood vessels, but then so does insulin. IMHO it's best to keep both at a minimum.

Bob

Sad but true. A great friend is t1d and is having trouble controlling blood sugar.....keeps on buying and eating junk food. Despite my attemps to help her see another way, but she is not interested.

They eat sugar and then inject more insulin to combat it. Both end up burning blood vessels.

It's sad, but you can only do so much for your friends and relatives. You can point the way, but can't force them and remain friends.

To some people, the pleasures of sweetness is worth the risk. I don't understand that concept, but it's common.

Bob

My MIL use to do the same thing. In fact she got remarried in later life and he put her on insulin just so they could make and eat cakes, pies and jelly they made. He also canned beets adding tons of sugar. That was before I understood all of this about diabetes but still we knew this wasn't how it was supposed to work.

I have two sisters like that. Ice cream rules. I don’t get it either.

I miss Harvard beets....not enough to make them though.

DANDR listed a study looking at dog arteries. Insulin injections roughened up the inside of the artery. That scared me straight.....insulin while important, is dangerous at high levels.

As a teen with an eating disorder it was because this was the drug I could afford to deal with stress. Once I moved out and reduced the stress, I was able to recover.

After bariatric surgery on thousands of people they discovered that ignoring their existing coping strategies that were food based can drive these people to alcohol instead.