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Originally Posted by Liz53
Interesting, JEY. I suspect no one really understands exactly under what conditions protein converts to glucose. I'd love to know Benay's opinion on these studies and I'd love to see more studies. That website has always seemed very credible, very balanced, to me.
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Well Liz, I went to the website and read the blog on gluconeogenesis mentioned by Jey. At your request, here is my 'take' on that blog post.
http://www.ketotic.org/2012/08/if-y...es-it-turn.html
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Author’s introduction: “We have seen the claim that any protein you eat in excess of your immediate needs will be turned into glucose by spontaneous gluconeogenesis ¹. (Gluconeogenesis (GNG) is the process by which glucose is made out of protein in the liver and kidneys.) Some people think that because protein can be turned into glucose, it will, once other needs are taken care of, and that therefore keto dieters should be careful not to eat too much protein.
While we believe there are valid reasons for limiting protein intake, experimental evidence does not support this one. In our opinion, it makes sense physiologically for GNG to be a demand-driven rather than supply-driven process, because of the need to keep blood glucose within tight bounds.”
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First study cited lasted only 11 days
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– Comment: is 11 days long enough for the body to convert to a stable gluconeogenesis? I don’t know. We do not know the parameters of the keto diet or anything about the sample. Clinical trials/experiments are only generalizable to similar groups and not to everyone on a keto or low carb diet. (Researchers define a low-carb diet differently by amount of carb grams. Do keto researchers have as wide a variation in their definitions of keto diets?)
2nd study
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“subjects on a glycolytic, or carb-based, rather than a ketogenic diet” ingested 50 gm protein with no appreciable effect
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Comment: Too little information to judge the validity of the study.
3rd study
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“There are other experiments in which increasing the available material for GNG to high levels didn't increase GNG ³, ⁴. In these experiments GNG substrates were infused directly into the blood rather than eaten”
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Comment: Since normal people eat protein rather than take it IV,, are these studies relevant to the discussion? Even people who are tube fed would have to digest their protein and the digestive process may influence the results.
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The authors conclude:
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“Summary: In sum, then, there is no evidence that we could find that consuming excess protein will increase glucose production from GNG. On the other hand, there is much suggestive evidence that it does not.”
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Liz, I did not find these studies convincing, although the authors of this blog appear convinced. We don’t have the studies themselves from which to judge but what we have I am not convinced.
Gluconeogenesis appears to be relevant only in the face of extremely low or no carbs but even that needs to be defined clearly and given a range that all people will fall into (for example obese versus lean, 20 yr old versus 70 year old, male versus female, metabolic disease or not).
The variability of the current studies in terms of design will affect outcomes. Until we can tease out differences in sample selection, variables and their controls, and length of the study, we just don’t have much solid ground to work from to draw conclusions.
I have accepted the 30% protein guideline without questioning it until Westman et al suggested “hold down the protein, don’t go overboard.” I would need to re-read Volek and Phinney for their definition even if they were just interested in lean hi-performance athletes.
PS What did you think of the Quest bar Liz? Which one did you choose? What did it say on the nutrition label about carbs (total, sugar alcohol, fiber, sugar), protein and fat? Just curious.