Active Low-Carber Forums
Atkins diet and low carb discussion provided free for information only, not as medical advice.
Home Plans Tips Recipes Tools Stories Studies Products
Active Low-Carber Forums
A sugar-free zone


Welcome to the Active Low-Carber Forums.
Support for Atkins diet, Protein Power, Neanderthin (Paleo Diet), CAD/CALP, Dr. Bernstein Diabetes Solution and any other healthy low-carb diet or plan, all are welcome in our lowcarb community. Forget starvation and fad diets -- join the healthy eating crowd! You may register by clicking here, it's free!

Go Back   Active Low-Carber Forums > Main Low-Carb Diets Forums & Support > Low Carb Health & Technical Forums > Dr.Bernstein & Diabetes
User Name
Password
FAQ Members Calendar Mark Forums Read Search Gallery My P.L.A.N. Survey


Reply
 
Thread Tools Display Modes
  #1   ^
Old Fri, Jun-15-01, 10:31
tamarian's Avatar
tamarian tamarian is offline
Forum Founder
Posts: 19,570
 
Plan: Atkins/PP/BFL
Stats: 400/223/200 Male 5 ft 11
BF:37%/17%/12%
Progress: 89%
Location: Ottawa, ON
Lightbulb Transplanted Pig Cells Help Control Diabetes

Friday June 15 8:44 AM ET

Transplanted Pig Cells Help Control Diabetes

By Patricia Reaney

LONDON (Reuters) - A baboon injected with pancreatic pig cells could be the beginning of the end of daily insulin injections for millions suffering from diabetes, scientists said on Friday.

Since researchers at Duke University in North Carolina injected a diabetic baboon called Babs-92 with specially encapsulated insulin-producing cells from pigs nine months ago the primate has not required any insulin to control the disorder.

If Babs continues to do well Dr. Emmanuel Opara and a team of scientists at Duke believe human trials of the technique could begin within two years.

``Once we can replicate the results in clinical trials, I think it could be the end of daily injections,'' Opara, an associate research professor of experimental surgery and cell biology, said in a telephone interview.

Insulin injections are not a cure for diabetes. They help diabetics control their blood sugar levels but the injections do not reduce their risk of developing other serious complications such as kidney failure, heart disease and strokes.

Opara believes the pig cell transplant could be a potential cure for many sufferers of the disease that afflicts an estimated 135 million worldwide, because in addition to providing insulin patients would also receive C-peptide, a precursor form of insulin.

``We know it is very, very helpful in preventing the complications of diabetes,'' Opara, who presented his research at an international transplant meeting in Innsbruck, Austria, explained.

PROTECTIVE COATING

The cells can be injected into the abdomen of humans using minimally invasive surgical techniques, Opara said.

``We do not know how many patients with diabetes would need this therapy, but the baboon data to date is very encouraging,'' he added.

Insulin is a hormone produced by cells in the pancreas which controls blood sugar levels and metabolism. People suffering from Type I diabetes have cells that do not work properly and they need daily insulin injections.

Opara and his team coated the pig cells with a complex carbohydrate known as alginate, which provides a protective sphere, and injected them into the Babs-92's abdominal cavity. Five more baboons have also received pig cells.

The coating acts as a one-way door that allows the insulin out but the baboon's antibodies and immune cells that attack the transplant cannot get in, which eliminates the need for anti-rejection drugs.

Opara said he was not sure how many cells will be needed for a human transplant but be believes the more than 90 million pigs that are used for food production in the United States each year should assure a steady supply.

The technique, if proven effective and safe, could help Type 1 diabetes sufferers and Type 2, or adult onset, diabetics who need injections.

http://dailynews.yahoo.com/h/nm/200...betes_dc_6.html
Reply With Quote
Sponsored Links
  #2   ^
Old Fri, Jun-15-01, 11:25
r.mines's Avatar
r.mines r.mines is offline
Senior Member
Posts: 1,383
 
Plan: Atkins
Stats: 162/124/120 Female 5'1"
BF:
Progress: 90%
Location: Vancouver,BC
Default

Well, this is good news for two friends of mine - one my age, and one young adult - who have type 1 diabetes. Jim, the guy who's my age, has already lost a leg to diabetes, and is worried about the other one....I've known him since we were kids, and I hate to see this happening to him. My other friend, Chris, is your 'typical' young guy who's not too clued in to his body and what he needs to do to optimise his health - he still smokes, for instance. Aaargh!!!

As for me, who is (am?) faced with adult onset diabetes if I'm not careful ..... I'd rather low carb!

Rachel
Reply With Quote
  #3   ^
Old Fri, Jun-15-01, 11:36
DebDaCajun's Avatar
DebDaCajun DebDaCajun is offline
Registered Member
Posts: 66
 
Plan: Dr. Bernstein
Stats: 290/270/150
BF:
Progress:
Location: Shreveport, LA
Default

Quote:
Originally posted by r.mines
As for me, who is (am?) faced with adult onset diabetes if I'm not careful ..... I'd rather low carb!


You and me both, sister! (I think I would have avoided the whole is/am conundrum by rephrasing -- I'm sometimes confused myself and have to yell out to my English teacher roomie for clarification )
Reply With Quote
  #4   ^
Old Fri, Jun-15-01, 12:53
doreen T's Avatar
doreen T doreen T is offline
Forum Founder
Posts: 37,202
 
Plan: LC paleo/ancestral
Stats: 241/188/140 Female 165 cm
BF:
Progress: 52%
Location: Eastern ON, Canada
Default

Quote:
Originally posted by tamarian
Opara said he was not sure how many cells will be needed for a human transplant but be believes the more than 90 million pigs that are used for food production in the United States each year should assure a steady supply.
Until the development of bio-synthetic human insulin analogs in the mid-80s, pork insulins were the most commonly used and available -- beef insulins were less stable, and less beneficial for humans. Porcine tissue is very close to human, and widely used ... skin grafts for burn victims, and heart valve-replacements spring to mind.

This holds real promise ... what a breakthrough!

Doreen
Reply With Quote
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

vB code is On
Smilies are On
[IMG] code is On
HTML code is Off

Similar Threads
Thread Thread Starter Forum Replies Last Post
Celebrity Chefs Across the Nation Crusade for Diabetes Awareness tamarian Dr.Bernstein & Diabetes 3 Tue, Dec-07-04 16:38
Bigger children at risk of type 1 diabetes doreen T Dr.Bernstein & Diabetes 4 Fri, Apr-12-02 17:17
Study Links 'Western' Diet with Adult Diabetes tamarian LC Research/Media 1 Mon, Feb-04-02 23:47
Type 2 diabetes increasing in KIDS - scary! doreen T Dr.Bernstein & Diabetes 1 Mon, Jul-23-01 22:47
Fat cell defect may lead to insulin resistance doreen T LC Research/Media 0 Mon, Feb-12-01 10:49


All times are GMT -6. The time now is 02:43.


Copyright © 2000-2024 Active Low-Carber Forums @ forum.lowcarber.org
Powered by: vBulletin, Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.