Active Low-Carber Forums
Atkins diet and low carb discussion provided free for information only, not as medical advice.
Home Plans Tips Recipes Tools Stories Studies Products
Active Low-Carber Forums
A sugar-free zone


Welcome to the Active Low-Carber Forums.
Support for Atkins diet, Protein Power, Neanderthin (Paleo Diet), CAD/CALP, Dr. Bernstein Diabetes Solution and any other healthy low-carb diet or plan, all are welcome in our lowcarb community. Forget starvation and fad diets -- join the healthy eating crowd! You may register by clicking here, it's free!

Go Back   Active Low-Carber Forums > Main Low-Carb Diets Forums & Support > Low-Carb Studies & Research / Media Watch > LC Research/Media
User Name
Password
FAQ Members Calendar Mark Forums Read Search Gallery My P.L.A.N. Survey


Reply
 
Thread Tools Display Modes
  #1   ^
Old Wed, Oct-14-20, 12:06
Demi's Avatar
Demi Demi is offline
Posts: 26,664
 
Plan: Muscle Centric
Stats: 238/153/160 Female 5'10"
BF:
Progress: 109%
Location: UK
Default Obesity risk linked to gene that drives inflammation

Obesity risk linked to gene that drives inflammation

https://www.thechronicleherald.ca/n...mmation-509158/

Quote:
Ottawa scientists have found a link between a gene involved in tissue inflammation and obesity that offers new hope for people who suffer from the complex disease.

The study, recently published in the journal Nature Metabolism, established that elevated levels of the molecule RIPK1 – it plays a role in driving inflammation in the body – predispose people to obesity. Scientists found that people with mutant copies of the gene that expressed RIPK1 were more likely to be obese.

For years, scientists have understood that obesity causes inflammation, but this is the first time that they’ve proven the reverse is also true: that a gene involved in inflammation causes obesity.

“Our work here is significant because it proves for the first time that an inflammatory factor predisposes people genetically to obesity,” said Dr. Katey Rayner, director of the cardiometabolic microRNA laboratory at the University of Ottawa Heart Institute.

Rayner, principal investigator of the study, said heart disease and obesity share a number of risk factors and mechanisms.

Eating too much creates an immune response in the human body, which in turn triggers the kind of inflammation that has been tied to a number of chronic diseases, including arthritis and heart disease.

Scientists have, for years, understood that obesity has a genetic component: that genes related to appetite control and metabolism – the way that calories are processed by an individual – can be inherited.

Rayner said the discovery of RIPK1’s role in obesity will give scientists a whole new avenue to explore for potential treatments.

“There are things in our genes that we can’t control and that are affecting our biology: this is one of them,” Rayner said. “From a therapeutic perspective, it gives a whole new biology to target for obesity. It’s not appetite and it’s not calories.”

Rayner’s lab proved the association between RIPK1 and obesity through a genetic analysis of people with obesity and a study that examined what happens when the gene is turned off in mice.

Researchers found elevated levels of the RIPK1 gene in the fat tissue of obese people, and further analysis showed that people with a mutant copy of the gene tended to be more obese. About 8 to 12 per cent of the poplulation have variations in the RIPK1 gene.

When researchers gave mice a drug that blocked the expression of RIPK1, the mice remained at a normal weight even though eating a high-carlorie diet. Their risk of diabetes was also reduced.

The treatment had no effect on the lean body mass of the mice.

“I think the most exciting thing from the average person’s perspective is that these mice were able to continue to eat and act how they wanted – and they still did not gain weight,” said Rayner.

Rayner, however, cautioned that it’s unlikely that scientists will be able to develop a single pill that will allow people to eat as much as they want without the need to exercise.

“For sure, this is not going to be a complete magic bullet,” she said. “But for the person who is doing all the other things to combat obesity and all its complications, this will hopefully give them a completely separate way to do it, and add it on top of all the other things we have to curb obesity.”

Obesity is known to increase the risk of other health problems, including heart disease, diabetes, arthritis, high blood pressure and some cancers. According to Statistics Canada , almost 27 per cent of Canadian adults – about 7.3 million people – can be classified as obese based on their height and weight.

Reply With Quote
Sponsored Links
  #2   ^
Old Wed, Oct-14-20, 14:17
Ms Arielle's Avatar
Ms Arielle Ms Arielle is offline
Senior Member
Posts: 19,177
 
Plan: atkins, carnivore 2023
Stats: 200/211/163 Female 5'8"
BF:
Progress: -30%
Location: Massachusetts
Default

Very cool stuff !!

Quote:
Eating too much creates an immune response in the human body, which in turn triggers the kind of inflammation that has been tied to a number of chronic diseases, including arthritis and heart disease.


So what is the answer to manage the expression of this gene??

Fasting ??
Reply With Quote
  #3   ^
Old Wed, Oct-14-20, 18:03
Zei Zei is offline
Senior Member
Posts: 1,596
 
Plan: Carb reduction in general
Stats: 230/185/180 Female 5 ft 9 in
BF:
Progress: 90%
Location: Texas
Default

It's not clear to me if they mean eating too much specifically triggers the gene in question or if the above quote of theirs is just another example of the common but misguided belief that people get obese because they just eat too much, when the truth is so much more physiologically complex, as the discovery of this gene is evidence of.
Reply With Quote
  #4   ^
Old Thu, Oct-15-20, 03:22
WereBear's Avatar
WereBear WereBear is offline
Senior Member
Posts: 14,608
 
Plan: EpiPaleo/Primal/LowOx
Stats: 220/125/150 Female 67
BF:
Progress: 136%
Location: USA
Default

My take is how they have it backwards: we know inflammation, overweight, and high processed carb intake all go together, but I swear so many have a mental block about that.
Reply With Quote
  #5   ^
Old Thu, Oct-15-20, 08:18
GRB5111's Avatar
GRB5111 GRB5111 is offline
Senior Member
Posts: 4,036
 
Plan: Very LC, Higher Protein
Stats: 227/186/185 Male 6' 0"
BF:
Progress: 98%
Location: Herndon, VA
Default

Quote:
Originally Posted by WereBear
My take is how they have it backwards: we know inflammation, overweight, and high processed carb intake all go together, but I swear so many have a mental block about that.

Important point. If these were simply treated as symptoms of an overall cause (Insulin Resistance and Metabolic Syndrome are the likeliest candidates), treatment options would be clearer and with that clarity, more targeted to address the root cause.
Reply With Quote
  #6   ^
Old Thu, Oct-15-20, 19:02
deirdra's Avatar
deirdra deirdra is offline
Senior Member
Posts: 4,324
 
Plan: vLC/GF,CF,SF
Stats: 197/136/150 Female 66 inches
BF:
Progress: 130%
Location: Alberta
Default

To me, eating too much of the wrong foods is what creates an immune response. For me, those are grains, legumes & dairy. Miniscule amounts of those foods still caused inflammation. I've never gotten inflamed from eating too much beef. While still eating dairy, and only 1200 cals/day I always retained 15 lbs of inflammation.
Reply With Quote
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

vB code is On
Smilies are On
[IMG] code is On
HTML code is Off



All times are GMT -6. The time now is 05:32.


Copyright © 2000-2024 Active Low-Carber Forums @ forum.lowcarber.org
Powered by: vBulletin, Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.