Thu, May-02-19, 02:00
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Plan: Muscle Centric
Stats: 238/153/160
BF:
Progress: 109%
Location: UK
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Why brown fat has a lot of nerve
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Why brown fat has a lot of nerve
Brown fat in mammals burns stored calories by producing heat, in a process that is controlled by nerves infiltrating this tissue. A protein that regulates innervation of brown fat and heat generation has been discovered.
The dramatic rise in obesity has led to a global increase in diabetes and cardiovascular disease. Excess calories in mammals are stored as triglyceride molecules in white adipose tissue (also known as white fat). By contrast, brown adipose tissue (BAT; brown fat) burns fat and glucose molecules to generate heat in a process called adaptive non-shivering thermogenesis1. Activating BAT thermogenesis is a potential strategy for combating obesity, so there is great interest in understanding the development and physiology of this tissue. Writing in Nature, Zeng et al.2 report that the protein calsyntenin 3β (CLSTN3β), found in brown fat cells, acts as a crucial regulator of BAT innervation and thermogenesis by controlling the secretion of a growth factor, the protein S100b.
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https://www.nature.com/articles/d41586-019-01278-4 |
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