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  #1336   ^
Old Fri, May-08-20, 07:36
Ms Arielle's Avatar
Ms Arielle Ms Arielle is offline
Senior Member
Posts: 13,781
Plan: atkins
Stats: 255/214/153 Female 5'8"
Progress: 40%
Location: Massachusetts

Feeling great so far (started end of March). I've got plenty of body fat to fuel me on non eating days and, fortunately for me, hunger is not an issue on fasting days. I don't know why this is - lucky I guess.

In my experience, when body is fat adapted, fasting day is not a hunger day. Just a keep busy and dont meal prep day, as fitting in meals is so normal it is habit.
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  #1337   ^
Old Fri, May-08-20, 08:25
Benay's Avatar
Benay Benay is offline
Senior Member
Posts: 642
Plan: Atkins
Stats: 200/177.5/175 Female 5 feet 6 inches
Progress: 90%
Location: Prescott, Arizona, USA

Originally Posted by Ms Arielle
We all have baggage that affects our relationship with food.

Never before has anyone reduced my experience to "baggage"
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  #1338   ^
Old Wed, May-27-20, 03:26
Demi's Avatar
Demi Demi is offline
Posts: 22,968
Plan: Keto/IF
Stats: 217/191/160 Female 5'10"
Progress: 46%
Location: UK

Warwick researchers discover how cells activate autophagy genes during fasting

As modern life-styles and high calorie diets drive the UK's obesity levels up, researchers from the University of Warwick have found how cells respond to fasting and activate the process called autophagy, which means a healthier lifestyle can be promoted to help people maintain a healthy body weight.

The UK has the highest level of obesity in Western Europe, with its levels having more than trebled in the last 30 years, it is estimated that more than half of the population could be obese by 2050 in UK. Obesity is a significant risk factor for increased morbidity and mortality. The cause of the rapid rise in obesity has been blamed on modern lifestyles, including high-calorie diet.

Intermittent fasting, alternate-day fasting, and other forms of periodic caloric restriction are beneficial to maintain a healthy body weight and have gained popularity during the last few years. To respond to fasting, cells use autophagy, a cellular self-recycling process.

A team of researchers led by Professor Ioannis Nezis from the School of Life Sciences, University of Warwick, discovered how cells activate autophagy genes during fasting. In the paper titled 'Regulation of expression of autophagy genes by Atg8a-interacting partners Sequoia, YL-1 and Sir2 in Drosophila', published in the journal Cell Reports on the 26th May, Dr Anne-Claire Jacomin, Dr Stavroula Petridi, PhD student Marisa Di Monaco and Professor Ioannis Nezis have discovered proteins which are required for the transcription of autophagy genes.

The proteins are called Sequoia, YL-1 and Sir2, these proteins interact with the cytoplasmic autophagy-related protein Atg8a. These interactions recruit Atg8a in the nucleus to control the transcription of autophagy genes. This is the first study that uncovers a nuclear role of the cytoplasmic protein Atg8a.

Understanding the molecular mechanisms of activation of autophagy genes during fasting will help us to use interventions to activate the autophagic pathways to maintain a normal body weight and promote healthy well-being."

Professor Ioannis Nezis, Lead author of the research, School of Life Sciences, University of Warwick

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  #1339   ^
Old Wed, May-27-20, 07:46
GRB5111's Avatar
GRB5111 GRB5111 is offline
Posts: 3,424
Plan: Ketogenic (LCHFKD)
Stats: 227/186/185 Male 6' 0"
Progress: 98%
Location: Herndon, VA

Thanks, Demi. This is good news and the more autophagy is studied, the more humans will be able to leverage the mechanism for improving health. Knowing when autophagy is triggered in the absence of food and being able to use it to one's advantage are beneficial. Further studies will help, and it's encouraging we are now peeling the onion's layers.
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