Is it just me who finds this logic to be quite twisted?
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The study authors said they could not be sure if excess body weight causes the hypothalamus to grow in size, or whether people with a larger hypothalamus are predisposed to eat more. The two may also both interact to increase the other, causing a feedback loop.
Studies in animals show that a high-fat diet causes inflammation of the hypothalamus, which in turn prompts insulin resistance and obesity. This inflammation can raise the threshold at which animals are full, meaning they have to eat more food than usual to feel full.
The lead author, Dr Stephanie Brown, from Cambridge’s department of psychiatry, said: “If what we see in mice is the case in people, then eating a high-fat diet could trigger inflammation of our appetite-control centre. Over time, this would change our ability to tell when we’ve eaten enough and to how our body processes blood sugar, leading us to put on weight.”
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If a high fat diet is what causes the hypothalamus to enlarge to begin with, and then - and ONLY then - lead to faulty processing of blood sugar, increased appetite, and eventual weight gain, then how are little kids raised on low fat diets with no exposure to high fat foods becoming fat?
My mother simply did not use more than very minimal fats in her cooking, because she couldn't stand "grease" and felt sick on more than very minimal amounts of fats. We all ate the same food: the same vegetables, the same starches, the same meats. How is it that I was the only one in the family who managed to get enough excess fat in my diet to cause my hypothalamus to enlarge when I had no control over my diet, and was being fed the same very low fat diet as the rest of the family?
But of course this phenomena of enlarged hypothalamus on a high fat diet was observed in mice, and extrapolated to apply to humans, despite the fact that humans are not mice and mice are not humans.
Ms A said:
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How hard is it to look at brains of thin people?? Where was that data?
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If they don't do that, then the whole theory is pretty meaningless.
Also, you know how naturally thin influencers will pull these stunts where they intentionally gain 20 or 40 lbs and then lose it just to prove that their weight loss method is the fastest or best way to lose weight and/or it's not that difficult to lose weight?
They need to study the hypothalamus of those people too - If in fact a high fat diet truly is to blame for an enlarged hypothalamus in humans, and the enlarged hypothalamus is what truly sets off the tendency for humans to gain weight, then they should be able to see that enlarged hypothalamus in them at their high weight - and that in turn should make it far more difficult for them to lose the weight they intentionally gained, much less keep it off.
The influencers are already doing half the experiment by eating excess amounts of food (and most likely very high fat to take in enough calories to gain that much weight). Might as well take the next step and find out what effect this has on their hypothalamus to either prove or refute their theory.