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  #61   ^
Old Wed, Mar-11-09, 10:05
capmikee's Avatar
capmikee capmikee is offline
Senior Member
Posts: 5,160
 
Plan: Weston A. Price, GFCF
Stats: 165/133/132 Male 5' 5"
BF:?/12.7%/?
Progress: 97%
Location: Philadelphia
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Maybe so, Nancy, but when I read the list of foods high in K2, it was like a shopping list for me and Janine - all our favorite foods were there - for me, ghee, goose liver, egg yolk, hamburger, beef liver and sauerkraut; for her, cheese, salami, egg, butter and bacon. Many of those have A, D, and multiple minerals as well. Not so difficult!
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  #62   ^
Old Wed, Mar-11-09, 10:05
Nancy LC's Avatar
Nancy LC Nancy LC is offline
Experimenter
Posts: 25,865
 
Plan: DDF
Stats: 202/185.4/179 Female 67
BF:
Progress: 72%
Location: San Diego, CA
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I guess go discuss it with Dr. Cannell and the other researchers that published the paper on Retinol and D. He does accept questions and answer them in his newsletter, perhaps he could help you resolve that question.

He does have interesting things to say about his reception at WAPF.
Quote:
I admired everyone I met at the Weston A. Price Foundation when I spoke there several years ago, mainly because of their commitment to healthy soil. However, when I brought up toxicity of cod liver oil, the atmosphere quickly turned from science to religion. Not only did I warn them about cod liver oil, the vitamin A researcher they flew in, Dr. Noel Solomon, also warned them about cod liver oil. No use. With every word either of us spoke, the flasks flashed as members of the audience took swigs of their cod liver oil.
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  #63   ^
Old Wed, Mar-11-09, 10:08
Jayppers's Avatar
Jayppers Jayppers is offline
Senior Member
Posts: 651
 
Plan: Mostly carnivory
Stats: 145/145/145 Male 5'11'' (feet and inches)
BF:
Progress: -20%
Location: Ohio
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Quote:
Originally Posted by Nancy LC
I've been reading the Vitamin D council newsletter for quite awhile and I've never ever heard anything about having to combine a bunch of other supplements with D3.
Vitamin D works in concert with other nutrients and co-factors. Just because it hasn't been stated outright in the newsletter does not mean that it may not be true; However, you may wish to note this excerpt from the most recent Vitamin D Coucil Newsletter:

Quote:
Originally Posted by John Jacob Cannell MD

Vitamin D Newsletter March 2009

To work properly, vitamin D needs magnesium, vitamin K, zinc, and probably boron. We hope to soon have a complete vitamin D on the market with all these co-factors...
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  #64   ^
Old Wed, Mar-11-09, 10:08
Nancy LC's Avatar
Nancy LC Nancy LC is offline
Experimenter
Posts: 25,865
 
Plan: DDF
Stats: 202/185.4/179 Female 67
BF:
Progress: 72%
Location: San Diego, CA
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Quote:
Originally Posted by capmikee
Maybe so, Nancy, but when I read the list of foods high in K2, it was like a shopping list for me and Janine - all our favorite foods were there - for me, ghee, goose liver, egg yolk, hamburger, beef liver and sauerkraut; for her, cheese, salami, egg, butter and bacon. Many of those have A, D, and multiple minerals as well. Not so difficult!

Yeah, but you're not obsessing over having to take them at a particular time with another vitamin. I take K2 and Magnesium but not because I feel like I have to because I'm taking D3, I just think they're healthy and I'm not sure I get enough of either.
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  #65   ^
Old Wed, Mar-11-09, 10:21
capmikee's Avatar
capmikee capmikee is offline
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Posts: 5,160
 
Plan: Weston A. Price, GFCF
Stats: 165/133/132 Male 5' 5"
BF:?/12.7%/?
Progress: 97%
Location: Philadelphia
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Okay, Nancy, you convinced me to go look up Dr. Cannell. I think he may be right about some things - The WAPF article I just read said that cod liver oil didn't have much K2. Weston A. Price combined cod liver oil with high K2 butter oil, so that suggests to me that Cannell was right, at least as far as to say modern cod liver oil should not be taken on its own.

But I detect a bit of religion in his own tone here:

Quote:
The idea that the human genome evolved eating liver is absurd. By the time humans could hunt large mammals, the genome had already evolved. Humans evolved eating a diet not dissimilar to the Great Apes: vegetables, fruit, roots, and some bugs. As far as us eating all kinds of liver, have you tried polar bear liver lately? Or sled dog liver? One serving can be fatal. There is evidence that later humans, when they learned to bring down large mammals, suffered vitamin A toxicity, probably from the liver they began consuming.


Cannell refers to several studies. Obviously the studies where pregnant women took cod liver oil are relevant, but when he says "The crux of the problem is that a form of vitamin A, retinoic acid, weakly activates the vitamin D response element on the gene and perhaps blocks vitamin D's more robust activation," I'm a little suspicious. The WAPF site claims that retinoic acid is a synthetic form of Vitamin A, so presumably any studies related to retinoic acid would not be relevant to cod liver oil. Now, I've seen errors on the WAPF site before, but I'd like to hear some confirmation on whether cod liver oil contains retinoic acid, and if it's in the same form as the studies that showed its toxicity.

I've been looking for accounts of fatal polar bear liver overdose and I haven't heard any. I wonder, though, if liver is a better food in lower latitudes. The Eskimos don't eat much liver, do they? The people that Price noted for liver consumption lived in Africa. Then again, the people famous for cod liver oil are the Norwegians.

Last edited by capmikee : Wed, Mar-11-09 at 10:41.
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  #66   ^
Old Wed, Mar-11-09, 10:52
Nancy LC's Avatar
Nancy LC Nancy LC is offline
Experimenter
Posts: 25,865
 
Plan: DDF
Stats: 202/185.4/179 Female 67
BF:
Progress: 72%
Location: San Diego, CA
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Keep reading, he's got a lot of stuff about Retinol in his newsletter, spread out over several newsletters. He also mentions case reports of bone problems in people eating too much liver.

Yeah, the gorilla diet thing is ridiculous.
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  #67   ^
Old Wed, Mar-11-09, 11:05
lil' annie lil' annie is offline
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Posts: 1,276
 
Plan: quasi paleo + starch
Stats: 153/148/118 Female 5'4"
BF:
Progress: 14%
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Quote:
Originally Posted by amandawood
Vitamin D increases magnesium uptake, so if you are somewhat magnesium deficient (most experts in this field say we are), then it may be the case that it has been magnesium deficiency causing some of these problems, not the actual Vitamin D itself.

Do you supplement with magnesium as well as Vitamin D?

It would seem most unlikely that Vit D could cause such extreme tiredness, in fact, (though I don't have the book at hand), I am pretty sure that Mary Dan Eades mentions that in her book on minerals and vitamins as being one of the symptoms.

There was another poster called "meistro" and another called "brown59", I think, who posted about similar side effects. Meistro started taking extra magnesium and instantly felt a lot better (she posted in my journal if you want to look for her thank-you note!).

I would recommend looking into magnesium. Check out george-eby-research.com for one good place about this mineral.

Finally, if I'm preaching to the converted and you already know about magnesium, please forgive me.

amanda




I was told by someone that my Vit.D symptoms were due to a lack of magnesium.

I've quit both.

In future years, if I ever happen to feel I'm coming down with the flu, then I'll take a few high doses of D for a few days.

Elsewise, "nuts!" to both of them.

I had no idea that the bizarre symptoms we were getting here were due to magnesium. I can't tolerate any magnesium supplement, and I'm not spending any more money to find out more names of more magnesium supplements I can't tolerate.

Had I known that I'd need more mag, for high dose D, I would NEVER have high dosed, as I've been intolerant to magnesium my entire life.
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  #68   ^
Old Wed, Mar-11-09, 12:00
Jayppers's Avatar
Jayppers Jayppers is offline
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Posts: 651
 
Plan: Mostly carnivory
Stats: 145/145/145 Male 5'11'' (feet and inches)
BF:
Progress: -20%
Location: Ohio
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Quote:
Originally Posted by Nancy LC
Yeah, the gorilla diet thing is ridiculous.
Agreed.

I remain completely open minded to the idea of an excess of vitamin A causing problems in the presence of vitamin D deficiency, but I must admit that it is difficult to take recommendations about avoiding all preformed retinols, especially those found in natural, otherwise very nutrient dense foods, from someone who clearly doesn't share my views (and many other individuals) on human evolution and diet.
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  #69   ^
Old Wed, Mar-11-09, 13:39
Jayppers's Avatar
Jayppers Jayppers is offline
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Posts: 651
 
Plan: Mostly carnivory
Stats: 145/145/145 Male 5'11'' (feet and inches)
BF:
Progress: -20%
Location: Ohio
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Quote:
Originally Posted by capmikee
The WAPF site claims that retinoic acid is a synthetic form of Vitamin A, so presumably any studies related to retinoic acid would not be relevant to cod liver oil.
I have to partially agree. Retinoic acid in the context of a study like the one cited by the D council is a synthetic substance, probably used in isolation and directly as retinoic acid, which doesn't seem to follow nature's laws (loosing sight of the forest for the trees kind of thing); However, we humans do make and use retinoic acid, which is converted from dietary retinol (from cod liver oil, liver, butter, eggs, etc.) by retinol dehydrogenase to retinal, and then irreversibly oxidised to all-trans retinoic acid and finally isomerized into 9-cis retinoic acid.

But in such an experiment that uses direct retinoic acid, I would agree that this would not seem to be the same as using the natural parent forms of the nutrient (retinol) that are governed by certain controls in the body to regulate its conversion into the more active metabolites (like retinoic acid, etc.).

Even so, recent information from the WAPF identifies the importance of adequate vitamin A and 9-cis-retinoic acid in the following excerpt:

Quote:
Originally Posted by Sally Fallon
In order for vitamin D to activate the expression of its target genes, it must bind to the vitamin D receptor (VDR) and then combine with the retinoid X receptor (RXR), which is activated by a particular form of vitamin A called 9-cis retinoic acid. RESEARCHERS FROM SPAIN RECENTLY SHOWED THAT VITAMIN D CAN ONLY EFFECTIVELY ACTIVATE TARGET GENES WHEN ITS PARTNER RECEPTOR IS ACTIVATED BY VITAMIN A.

In the ABSENCE OF VITAMIN A, molecules called “corepressors” bind to the
VDR/RXR complex and PREVENT vitamin D from functioning.
Additionally...

Quote:
COD LIVER OIL IN PREGNANCY
The Annals paper does not cite any studies showing toxic effects from cod liver oil, but Dr. Cannell cites one study in his December newsletter associating intake of cod liver oil with hypertensive disorders during pregnancy. Users of cod liver oil in this study had about twice the intake of vitamins A and D as non-users and eight times the intake of long-chain omega-3 fatty acids. The study found the most robust association with longchain omega-3 fatty acids, which were associated with lower risk between 0.1 and 0.9 grams per day and higher risk above 0.9 grams per day. The authors suggested that the association with high blood pressure might be related to oxidative stress caused by a high intake of polyunsaturated fatty acids.
The lesson with that is to not forget that cod liver oil contains a myriad of components, and to conclude it is dangerous simply based on its vitamin A content is probably over-simplification of the matter.

Last edited by Jayppers : Wed, Mar-11-09 at 13:53.
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  #70   ^
Old Wed, Mar-11-09, 17:47
Zuleikaa Zuleikaa is offline
Finding the Pieces
Posts: 17,049
 
Plan: Mishmash
Stats: 365/308.0/185 Female 66
BF:
Progress: 32%
Location: Maryland, US
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Quote:
Originally Posted by capmikee

I've been looking for accounts of fatal polar bear liver overdose and I haven't heard any. I wonder, though, if liver is a better food in lower latitudes. The Eskimos don't eat much liver, do they? The people that Price noted for liver consumption lived in Africa. Then again, the people famous for cod liver oil are the Norwegians.
There have been reports of fatal polar bear liver overdose though most occurred many years ago.

I still look at that as a scare tactic though. There is no denying that polar bear liver is toxic. Polar bear liver has over 3 million IU of vitamin A per 3 ounces. Beef liver has over 3,000 IU of vitamin A per 4 ounces. So polar bear liver has over 1,000 times more vitamin A per 3 ounces raw than beef liver or any other animal liver even whale liver... There really is no comparison.

See my rant here http://forum.lowcarber.org/showthre...min#post6212936
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  #71   ^
Old Thu, Mar-12-09, 01:56
amandawald amandawald is offline
Senior Member
Posts: 4,737
 
Plan: Ray Peat (not low-carb)
Stats: 00/00/00 Female 164cm
BF:
Progress: 51%
Location: Brit in Europe
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Quote:
Originally Posted by lil' annie
I was told by someone that my Vit.D symptoms were due to a lack of magnesium.

I had no idea that the bizarre symptoms we were getting here were due to magnesium. I can't tolerate any magnesium supplement, and I'm not spending any more money to find out more names of more magnesium supplements I can't tolerate.

Had I known that I'd need more mag, for high dose D, I would NEVER have high dosed, as I've been intolerant to magnesium my entire life.


Hi there Lil' annie,

There are ways to get magnesium which don't involve ingesting it, such as putting Epsom Salts in a bath or foot bath (but only in lukewarm water, as it will heat you up) or using magnesium chloride in your bathwater. This way you will get your magnesium via your skin and not have any GI problems.

At least, that's what I've heard: I haven't ever actually tried it myself. I would google both magnesium chloride and Epsom Salts and see what you find. Other sources of natural magnesium which are well absorbed are bone broths (beef, chicken etc) and nuts. However, some would advise you to soak the nuts overnight and then to dry them out to get rid of the enzyme inhibitors.

Sorry to hear that you are intolerant to magnesium supplements. It really is an important mineral so you really need to make sure you're getting it in another form.

amanda
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  #72   ^
Old Thu, Mar-12-09, 07:22
lil' annie lil' annie is offline
Senior Member
Posts: 1,276
 
Plan: quasi paleo + starch
Stats: 153/148/118 Female 5'4"
BF:
Progress: 14%
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I mentioned earlier in the thread that I cannot take either full baths or foot baths without having violent diarhea, and even sprinkling a teaspoon of epsom salts in my shoes had the same effect - it just took alot longer due to the normally constipating effect of a very low carb diet.

I have celiac disease, and am not going to play around with magnesium supplements, not anytime soon, and in the past, I've already spent hundreds of dollars trying to find a magnesium supplement I could tolerate. I'm not spending more money on that.

I'll simply only take the Vitamin D when I happen to deem it absolutely necessary.

The requirement for extra magnesium certainly could explain why SOME individuals say that Vit.D doesn't help them at all.
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  #73   ^
Old Thu, Mar-12-09, 08:41
Jayppers's Avatar
Jayppers Jayppers is offline
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Posts: 651
 
Plan: Mostly carnivory
Stats: 145/145/145 Male 5'11'' (feet and inches)
BF:
Progress: -20%
Location: Ohio
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If a moderator stumbles across this post - please feel free to delete it - it is a duplicate. Thanks.

Last edited by Jayppers : Thu, Mar-12-09 at 09:07.
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  #74   ^
Old Thu, Mar-12-09, 09:06
Jayppers's Avatar
Jayppers Jayppers is offline
Senior Member
Posts: 651
 
Plan: Mostly carnivory
Stats: 145/145/145 Male 5'11'' (feet and inches)
BF:
Progress: -20%
Location: Ohio
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Quote:
Originally Posted by Zuleikaa
I still look at that as a scare tactic though. There is no denying that polar bear liver is toxic. Polar bear liver has over 3 million IU of vitamin A per 3 ounces. Beef liver has over 3,000 IU of vitamin A per 4 ounces. So polar bear liver has over 1,000 times more vitamin A per 3 ounces raw than beef liver or any other animal liver even whale liver... There really is no comparison.

See my rant here http://forum.lowcarber.org/showthre...min#post6212936
I agreee, Z. Thanks for sharing your rant post.

I think it is irresponsible for someone of medical stature in possession of influence to take human liver consumption (most typically from chickens, cows, lamb, goose, and duck) to the ultimate extreme of equating it with consuming polar bear liver. Stating the ill-effects of consuming polar bear liver as justification that our ancestors evolved without consuming vitamin A-rich foods like organs and liver is not correct, IMO. Polar bear liver just happens to be one of the few exceptions because of its known ability to produce toxicity, which traditional cultures were aware of.
Poison is in everything, and no thing is without poison. The dosage makes it either a poison or a remedy.” - Philipus Aureolus Paracelsus
Advising people to avoid liver consumption partly on the basis that polar bear liver is known to contain toxic levels of vitamin A for a human being is similar to advising people to avoid vitamin D supplementation of say 5K IUs per day because doses of 250K IUs (for example) can produce toxic effects, even though they can both be contained in the same size pill/capsule. A similar analogy might be drawn from wine consumption. It is clearly an overly simplistic generalization on the subject.
The art of healing comes from nature, not from the physician. Therefore the physician must start from nature, with an open mind.” - Philipus Aureolus Paracelsus

Last edited by Jayppers : Thu, Mar-12-09 at 09:20.
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  #75   ^
Old Thu, Mar-12-09, 10:11
capmikee's Avatar
capmikee capmikee is offline
Senior Member
Posts: 5,160
 
Plan: Weston A. Price, GFCF
Stats: 165/133/132 Male 5' 5"
BF:?/12.7%/?
Progress: 97%
Location: Philadelphia
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Quote:
Originally Posted by Zuleikaa

I finally got a chance to look at your rant. I had no idea small fish had such a high ratio of D:A! And that kidneys have more Vitamin D than liver - is that common for land animals? Or is it just that they don't have data on Vitamin D in liver? I dont think the ~ symbol necessarily means 0.

NutritionData does give cod liver oil a pretty high D:A ratio. I think the stuff I have at home, despite being one of the WAPF recommended "clean" brands, has about half as much Vitamin D.

Does canned herring have as much Vitamin D as raw? I love my kippers...

Hmm. Here are my own lookups from NutritionData, for 3oz servings, in IU of A/D:

kippered herring: 113/100
anchovies: 33/~
black & red caviar: 759/195
"mixed species" roe, raw: 251/~

So canned sardines (105/230) are better than kippers.

I wonder if the quality of roe is related to the quality of its vitamins - maybe my cheap carp tarama isn't as nourishing as the fancy sturgeon stuff.
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