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  #1696   ^
Old Thu, Oct-18-18, 10:34
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JEY100 JEY100 is online now
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The Grassroots Health website, https://www.grassrootshealth.net/bl.../breast-cancer/ has interesting and helpful articles on Breast Cancer and levels of Vitamin D for prevention through their own members of D*Action.
Finding so much in addition to this new study on D and breast cancer.
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  #1697   ^
Old Wed, Oct-31-18, 05:25
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Demi Demi is offline
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I know that she's probably too modest to post this here herself, but there's a very good article on GrassrootsHealth by Zuleika:

Vitamin D Can Turn Your Health Around

https://www.grassrootshealth.net/bl...-health-around/
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  #1698   ^
Old Thu, Nov-01-18, 03:56
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JEY100 JEY100 is online now
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Plan: P:E/DDF
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Thank you posting this article here, Demi

Zuleika, thank you for sharing your story and the all the excellent resources about breast cancer in it. My oncologist tests mine every year, but unsure if he does that now for every client in the practice. Next visit, plan to bring those special population studies. What a thought provoking article!
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  #1699   ^
Old Thu, Nov-01-18, 16:45
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Ms Arielle Ms Arielle is offline
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Plan: atkins, carnivore 2023
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Thanks Demi for putting up that link ----and thank you Z for sharing your story.

I have a son battling lymes, ADD and asbergers. And after just watching the BROKEN Brain series and searching on the internet, the bottom line is he needs to improve his immune system.

As for Vit D, his recent test came back at 38. The normal is 20-50. He is a thin skinny kid, so I need to be cautious about dosing yet feel he is in crisis and needs heavy dosing.

How long before asking for a retest do you think??
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  #1700   ^
Old Sun, Apr-07-19, 16:50
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JLx JLx is offline
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Plan: High protein, lower fat
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Quote:
Abstract:
Objective:
Vitamin D plays an important role in bone metabolism. There is now evidence that a higher serum level of 25-hydroxyvitamin D (25[OH]D) is associated with a lower risk of developing type 2 diabetes mellitus, because it provides better glycemic control, possibly by promoting greater insulin sensitivity, and also by improving pancreatic beta cell function. The objective of the present study was to evaluate the possible association between 25(OH)D sufficiency and glycemia.

Methods:
This was a cross-sectional study involving 680 women, 35 to 74 years of age, selected through systematic sampling. From each participant, fasting blood samples were collected for the determination of 25(OH)D and glucose levels.

Results:
The mean fasting blood glucose level was 105 mg/dL (range 26-401 mg/dL). Fasting serum levels of 25(OH)D were <30 ng/mL in 65.4% of the participants and <20 ng/mL in 25.6%. A serum 25(OH)D level <30 ng/mL was positively associated with a blood glucose level ≥100 mg/dL (odds ratio [OR] 1.29, 95% confidence interval [CI] 1.05-1.57), as was a serum 25(OH)D level <20 ng/mL (OR 1.25, 95% CI 1.04-1.50).

Conclusions:
Lower serum 25(OH)D concentrations appear to be associated with a high blood glucose levels.


https://journals.lww.com/menopausej...ated.97422.aspx
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  #1701   ^
Old Mon, Apr-08-19, 07:48
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Ms Arielle Ms Arielle is offline
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Im looking for information on VItamin A. Is it here in this thread or else where??? Vit A came to my attention when a boo-boo showed me the color of my body fat--- a rather pale yellowy gray. Not the rich yellow of chicken fat. The poor color got me thinking....
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  #1702   ^
Old Sun, May-26-19, 23:37
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Quote:
Top UK scientist urges people to take vitamin D supplements

Geneticist Steve Jones, formerly a sceptic, says case for doing so is overwhelming


One of Britain’s leading scientists has urged people to take vitamin D supplements, particularly children, who spend an hour less outside than they did 10 years ago.

The geneticist Steve Jones told the Hay literary festival in Wales the health case for taking them was now overwhelming. “I never thought I would be a person who would take vitamin supplements, I always thought it was absolute nonsense, it’s homeopathy. I now take vitamin D every day,” he said.

“Today, because I knew the sun wasn’t going to shine, I took an extra one.
“Children today spend an hour a day less outside than they did 10 years ago. That’s the smartphone and the tablet situation. Scottish children spend less time in the sun than any other children in the world.”

He said the bone disease rickets, which doctors thought they had eliminated from Britain in the 1950s, was a real issue today. “Rickets is coming back and rickets is coming back at some speed. It is coming back because of a shift in human behaviour which we never thought would happen,” he said.

Jones said the benefits of sunshine and vitamin D could be felt across a range of health areas including obesity, mood and blood pressure. He cited multiple sclerosis, which is most common in northern Canada and almost unheard of in tropical countries. In the UK, levels are higher in Scotland than England.

Scotland gets the least sunshine in the UK and Scottish men have a life expectancy two years less than men in England and Wales, he said. “Scotland is still the sick man of Europe. The Scots are the palest people in the world … and that’s because their entire body systems are crying out for vitamin D.”

Jones is professor of genetics at University College London and is considered one of the finest science communicators of his generation. He was in Hay talking about his new book, Here Comes the Sun.

Jones told the audience that vitamin D had many unexpected effects on the body, including the immune system. “It can help tackle infectious disease, it changes mood, if you have a shortage you’re more likely to get kidney disease … it is really, really important stuff. The evidence that the shortage of sunlight has drastic effects on health is overwhelming.”

The sun also lowers your blood pressure. “If you lie out on the beach in your bikini, or without anything on, for an hour you will drop your blood pressure by about 10 points, because it relaxes your blood vessels. So get out in the sun while we still can.”

Jones acknowledged that too much sun can cause skin cancer, a discovery made in the 1930s during research on the health of US Navy sailors. It was also discovered that they had lower levels of other diseases because of their greater exposure to the sun. “That was forgotten more or less, but it’s now being discovered in spades.”



https://www.theguardian.com/society...n-d-supplements


https://www.amazon.com/Here-Comes-P.../dp/1408711311/
https://www.amazon.co.uk/Here-Comes.../dp/1408711311/
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  #1703   ^
Old Mon, May-27-19, 00:28
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For the sake of our health, we need to kick the indoor habit

Vybarr Cregan-Reid

Spending too much time at home or in the office is confusing our bodies, which are telling us to get out more


As a species we need to get out more. Humans now spend so much time indoors that many of us are cultivating a variety of serious health complaints, and for some they could be fatal. It is not so much that outdoor time is inherently good; more that our bodies are built to anticipate it and the way we live now is confusing to our systems. Nearly two decades ago a study published in Nature magazine concluded that the average American spent 93% of their time indoors. And that was before tablets and smartphones.

In trying to cope with the shaded, sedentary world we have made, our bodies wage war on what should be harmless antigens; they fail to make bones strong enough to support our weight; even our eyes struggle to focus without the help of lenses. This incremental creep across the threshold to the great indoors began tens of thousands of years ago when the first settled communities emerged.

As our shelters have become larger and sturdier, the time that we spend in them has extended. And we are only just beginning to understand the number of health risks that are associated with living a permanently sheltered life. Take shortsightedness, which is a growing problem among the young, particularly in south-east Asia. Almost everyone believes that close work (reading, phone use, too much TV) plays a part. And, because the condition is more common in certain populations, coupled with the fact that parents seem likely to pass the condition on, many also believe that it is hereditary. While both assumptions are not wrong, they are a long way from telling the whole story.

In Singapore, for example, where I went with the BBC to make one of a series of programmes about how modern life is changing our bodies, myopia affects 85% of young people. The fact that only 30% of the older generation are shortsighted suggests that the current spike is not being driven by inherited genes.

To grow to its optimum shape, a developing eye needs exposure to good quality light, which can’t be found indoors. In Singapore, there are virtually no houses with gardens where children can play – only tower blocks. Even if they wanted to play outside, a hyper-competitive educational environment means that children are often buried under academic work. The city boasts miles of subterranean outlets that interconnect between main streets. All of which contribute to children’s exposure to artificial light.

Our indoor habits are so ingrained that many of us are also not getting enough vitamin D. To make bone, we need calcium and phosphorous, but calcium in particular is difficult for the body to absorb without vitamin D.
Although we can get some vitamin D through our diet, most of it is made by our skin on exposure to sunlight. There have been a number of infant deaths caused by vitamin D deficiency in Britain in recent years.

Research is also showing that vitamin D deficiency is increasingly linked with the prevalence of allergies. An allergic reaction is an inappropriate immune response (itching, swelling, anaphylaxis) to an otherwise harmless substance. With every generation since the 19th century, the number of children with allergies has seemingly increased exponentially. Asthma, for example, was practically unheard of 200 years ago, but today it accounts for 1,200 deaths a year in the UK.

Studies contrasting rural and modern populations have shown that exposure to “natural environments” may reduce allergy risks by more than 90%.

Historically, these figures make sense. Hay fever, when it began in the 19th century, was associated either with the bookish or the well-to-do, being two groups who spent little time working the fields. The second wave of allergic disease is food allergy. Research in Australia suggests that vitamin D deficiency is linked to an elevenfold increase in the likelihood of peanut allergy (and a tripling of the prevalence of egg allergy).

Around the world, various solutions are being sought with varying degrees of success. In China, there have been rather sketchy experiments with glass classrooms (they failed because everyone cooked in the heat). In Singapore, schools are introducing a variety of measures specifically to improve children’s exposure to sunlight. In some, playtimes are now of a greater length and frequency, lessons are deliberately timetabled so that students are required to walk longer distances between class. The experiments also have additional benefits such as curtailing children’s gadget time while building social engagement.

A smartwatch is being trialled for children in Singapore, which as well as tracking activity also calculates minutes of exposure to good quality light. The watches are collecting masses of data that in a few years’ time will prove invaluable in determining the ideal light diet for children throughout the world.

Our DNA does not expect us to be out hunting all day on the savannah. But what began with a few branches as an easy solution for settling in one place has since ballooned into a total shade-binge. If urban planning for the future is to succeed it needs to take into account everything that humans need: not just food, water and shelter, but sunlight, too.

The causes of our modern maladies are complex. But the uncomfortable truth is that too many of them are all finding their feet in the perennial shade afforded by our 21st-century lifestyles.

• Vybarr Cregan-Reid is the author of Primate Change: How the world we made is changing us



https://www.theguardian.com/comment...th-indoor-habit
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  #1704   ^
Old Tue, Jun-04-19, 01:36
Demi's Avatar
Demi Demi is offline
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From The Telegraph
London, UK
3 June, 2019

Vitamin D supplements can cut risk of dying from cancer, scientists find

Vitamin D could cut the risk of dying from cancer, according to research which suggests sunshine and supplements could save lives.

Scientists warned that modern lifestyles could be increasing the risk of disease, with ever longer hours spent indoors, or in the shadow of skyscrapers.

Research on almost 80,000 adults by Michigan State University and Hurley Medical Center found that taking a supplement for at least three years was associated with a 13 per cent drop in mortality from all cancers.

Another study by Madrid University Hospital found that taking a daily pill along with a statin was linked to a 38 per cent reduction in deaths from prostate cancer. Scientists from said the effects appeared to be independent of each other, suggesting that both the medication and the vitamin boosted survival.

A third study by Allegheny Health Network Cancer Institute, in Pittsburgh, suggested that a deficiency of vitamin D could double the risk of pancreatic cancer.

Researchers said GPs should prescribe supplements to ensure the population increased its intake of vitamin D.

The slew of studies, presented at the American Society of Clinical Oncology (ASCO) annual conference in Chicago, follow research suggesting that the vitamin could protect against heart disease, and diabetes, as well as helping bone strength.

The studies did not show why vitamin D might help cancer survival. But experts said it could enhance the body’s immune response, reducing the proliferation of tumour cells.

Dr Tarek Haykal, lead researcher from Michigan State University, said the findings were “promising” - and urged GPs to recommend supplements.

He said: “The take home message is that vitamin-D might carry a benefit for the cancer population. Patients who received vitamin-D supplementation for at least three years in any form, had significantly lower cancer-related deaths”.

Dr. Shifeng Mao, from Allegheny Health Network Cancer Institute, said modern lives made it difficult to get sufficient sunshine.

“We are living in a modern society with a fast-paced life style,” he said. “People spend significant amount of time at work in a concrete building and have much less time for leisure, let alone being exposed to nature and sunlight, so Vitamin D deficiency is prevalent.”

Three in four adults in Britain are deficient in the vitamin, some research suggests.

In 2016, health officials recommended that all adults should consider taking supplements, especially in the winter, and providing them for children over the age of one.

However, over-exposure to sunshine is linked to an increased risk of skin cancers, which have seen a sharp rise in the UK since the advent of cheaper travel, and package holidays.

Medics said pensioners could cut their risk of early death by up to 20 per cent by taking a supplement.

Dr Daniel Bikle, Professor of Medicine and Dermatology at University of California, San Francisco, said: “I’m a big believer in sensible sun exposure, getting some sun or your skin without burning. But in places such as the UK, there is not enough sun all year round, so supplements in the winter months are necessary.

Dr Rachel Shaw, from Cancer Research UK, said the studies did not prove that vitamin D prevented cancer developing.

She said: “It may improve prognosis when cancer develops - potentially in both those who take vitamin D preventatively, and those who take it in addition to their prescribed cancer treatments. “More research is required to determine who will benefit and the recommended dosage, so it’s important that cancer patients consult their doctor before taking vitamin supplements."



https://www.telegraph.co.uk/news/20...cientists-find/
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  #1705   ^
Old Wed, Jun-05-19, 02:24
Demi's Avatar
Demi Demi is offline
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Quote:
The 5:2 Sunshine Diet: how to get just the right amount of vitamin D to stay healthy

When Paul Banwell, a consultant plastic surgeon and skin cancer specialist, was doing his fellowship in Australia over ten years ago, he discovered a peculiar fact: virtually all the dermatologists he was working alongside in Sydney and Brisbane were vitamin D deficient. One even had a pathological fracture (a bone fracture caused by weak bones).

“They cover up in the sun the whole time over there, both with clothes and sun cream,” explains Banwell. “As a skin cancer expert myself, I tell patients to wear sunscreen every day, but in Australia they take the sun safety message to the extreme, and they’re lacking in vitamin D as a result.”

This anecdote may go some way to explaining the increasing levels of vitamin D deficiency worldwide. The sun safety message – which started with Australia’s 1981 Slip! Slop! Slap! public health campaign to reverse the country’s soaring rates of skin cancer – was so well absorbed by countries like the UK and US, that people's concern about protecting themselves from the sun meant they overlooked its health benefits. Namely, how it helps the body produce vitamin D.

Yet this week, a slew of studies presented at the American Society of Clinical Oncology annual conference in Chicago found that vitamin D – from both sunshine and supplements – could reduce your risk of dying from several types of cancer. The experts at the conference couldn’t say why, but suggested vitamin D may enhance the body’s immune response, and Dr Tarek Haykal, a lead researcher from Michigan State University, urged GPs to recommend supplements.

“We now know that good levels of vitamin D are linked with a reduced risk of a variety of different cancers,” says Paul Banwell. “At last count it was 15 types, with the main ones being colon, prostate, breast and skin. It’s a bizarre paradox that vitamin D from the sun actually helps to protect against skin cancer. It seems to be protective on a cellular level.”

The Chicago conference referenced studies that found those told to take vitamin D supplements were no less likely to get cancer, but were 13 per cent less likely to die from the disease. Supplements were linked to a 38 per cent drop in prostate cancer deaths, while the link with pancreatic cancer was also strong – being deficient in vitamin D can double your risk of developing it.

“Vitamin D is a fat-soluble vitamin stored in the body,” explains dietitian Helen Bond. “The sun is by far the best source, but you can also get it from food and supplements. For years we’ve known vitamin D maintains healthy bones. But in recent years, there has been a lot of new and exciting research suggesting it can help protect against certain cancers, Type 1 diabetes, cardiovascular disease, age-related macular degeneration, mental decline, multiple sclerosis and rheumatoid arthritis.”

Another study has found it can increase fertility in both men and women, improve the chances of IVF success, and help regulate menstrual cycles in women suffering from PCOS (polycystic ovary syndrome). Yet it’s thought one in four British adults are vitamin D deficient.

Not that it’s just over zealous sun safety driving this: the dreary British weather, and our increasingly busy, office-based, Netflix-addicted lives are also playing a part. “People spend significant amounts of time at work in a concrete building and have much less time for leisure, let alone being exposed to nature and sunlight, so vitamin D deficiency is prevalent,” said Dr Shifeng Mao, from Allegheny Health Network Cancer Institute, at the Chicago conference.

So just how much do we need? The NHS recommends babies up to the age of one need 8.5 to 10 micrograms of vitamin D (a microgram is 1,000 times smaller than a milligram). Children from the age of one need 10 micrograms of vitamin D a day.

With regards to taking a supplement, the Department of Health recommend breastfed babies be given a daily supplement of 8.5 to 10 micrograms of vitamin D each day (formula fed babies don’t need it, as formula milk is fortified with vitamin D), and children aged one to four be given a daily supplement containing 10micrograms. Adults should take the same amount from October through to the end of March – from then until the end of September, most people should get all the vitamin D they need from sunlight on their skin, according to the NHS website.

“Those particularly at risk of vitamin D deficiency include pregnant and breastfeeding women, people who work shifts or long hours, and those who cover most of their skin when outside (perhaps for religious reasons),” says Bond, who suggests also eating vitamin D-rich foods including oily fish, cod liver oil, full fat milk, eggs, mushrooms and yoghurt.

As for supplements, according to a recent report, the UK spends £7million on vitamin D supplements each year. Paul Banwell says that vitamin D3 appears to be the best – whether in spray, dropper or tablet form – and is the one he recommends his patients take daily.

There are five types of vitamin D, but the body primarily uses plant-based vitamin D2 and D3, which is found in animal products. The latter is more easily converted in the body, and a 2017 study from the University of Surrey found vitamin D3 is twice as effective as D2 in raising overall levels of vitamin D in the body. D3 can also help create calcium and protect against fractures and osteoporosis.

As for the sun, how best to strike the right balance? “While there are immense health benefits from the sun, it has its dark side,” says Banwell. "Fifteen minutes of unprotected sun exposure every day is sufficient, and comes with a psychological benefit too.” People with darker skin tones take longer to make vitamin D (although they should still be cautious of burning) and the more skin you expose, the less time you need in the sun.

Most experts advise against “sun-binging” and advocate “sun micro-dosing” instead – in other words, enjoying short bursts of sunshine, rather than longer periods of exposure which can increase your risk of burning, especially if you’re fair skinned. “The concept of micro-dosing sun exposure is a more attractive one as it limits the risk of sunburn,” says Banwell. “However, ultimately, cumulative sun exposure is directly proportional to skin cancer risk. The intensity of the UV radiation is also important, hence the significant risk of sun beds and tropical climates.

“What’s really interesting is the new generation of sun screens that are coming out of Australia that contain vitamin D precursors. One, called Rationale, has SPF in it to protect skin from the harmful effects of the sun, but it’s also light activated so UV rays are turned into vitamin D in the body.
Up until now, products like this have only been available in medical spheres,” and aren’t yet available to consumers, but watch this space: “they’re slowly making their way into the mainstream.”

The main take away from these new studies, says Banwell, “is to take a 5:2 approach to vitamin D – five parts good quality supplements, and two parts moderate, modest sun exposure. Along with a good vitamin-rich diet, this will ensure you get just the right amount to stay healthy all year.”



https://www.telegraph.co.uk/health-...d-stay-healthy/
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  #1706   ^
Old Thu, Jun-27-19, 03:07
Demi's Avatar
Demi Demi is offline
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Quote:
June 26, 2019

Muscling in on the role of vitamin D

by Westmead Institute for Medical Research


A recent study conducted at The Westmead Institute for Medical Research has shed light on the role of vitamin D in muscle cells. The study looked at the role of vitamin D in muscles in mice, and showed that vitamin D signaling (how cells communicate with one another) is needed for normal muscle size and strength.

Researchers found that mice missing the vitamin D receptor only in myocytes (muscle cells) had smaller muscles, and they were less strong. They also had significantly decreased running speed and didn't run as far as mice with normal vitamin D action.

Lead researcher, Professor Jenny Gunton says, "For a long time, we have known that vitamin D deficiency is associated with muscle weakness and greater risk of falls and fractures. However, whether vitamin D played a direct role in muscle wasn't known.

"We show that vitamin D receptor is present in low levels in normal muscle, and our study found that deleting muscle cell vitamin D receptors had important effects on muscle function."

Professor Gunton says that, compared to a previous study she conducted that looked at mice missing vitamin D receptors across their whole body, this new study has highlighted some important differences.

"We found that mice missing muscle cell vitamin D receptors had normal body size but less muscle mass and more fat mass.

"In terms of choosing to run on a wheel in their cage, the mice had shorter running distance and slower speed. These might contribute to the lower muscle mass and increase in fat.

In terms of muscle strength, these mice also had a significantly decreased grip strength from a very early age."

While more research is needed, Professor Gunton says that these results suggest that maintaining normal vitamin D signaling in muscle is important for preserving muscle bulk and function.

"These findings also have the potential to open up avenues to pursue new therapies that target muscle cell vitamin D receptors. These therapies could help to address or prevent age-related sarcopenia (degenerative loss of skeletal muscle mass) and other disorders related to muscle function."

The research paper was published in the Journal of Cachexia, Sarcopenia and Muscle.



https://medicalxpress.com/news/2019...-vitamin-d.html
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  #1707   ^
Old Thu, Jun-27-19, 03:12
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Demi Demi is offline
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Quote:
26 June, 2019

Vitamin D Recommendations Miss the Mark

BUDAPEST, Hungary — High doses of vitamin D₃ are safe and more effective in preventing bone fracture in kidney transplant recipients than standard recommended doses, according to the results of the VITALE (NCT01431430) study.

"Currently recommended doses of vitamin D are not sufficient to protect patients," said Marie Courbebaisse, MD, PhD, from Hôpital Européen Georges Pompidou in Paris.

"Our findings challenge advice in the current international KDIGO guidelines, which recommend using low doses of cholecalciferol, similar to those recommended for the general population," she said during a news conference here at the European Renal Association–European Dialysis and Transplant Association (ERA-EDTA) 56th Congress.

Vitamin D insufficiency is common in patients who have undergone kidney transplant because their intake is inadequate, their vitamin D catabolism is elevated, and they limit sun exposure to reduce the risk for skin cancer induced by antirejection therapies, Courbebaisse explained.

This study is important for nephrologists and their patients "because it shows that high-dose vitamin D is an effective way of lowering the rate of fractures after kidney transplantation, with a very low risk of any side effects," said ERA-EDTA President Carmine Zoccali, MD, from Ospedali Riuniti, Reggio Calabria, Italy.

All participants in VITALE had undergone kidney transplant in the previous 12 to 48 months and had serum 25-hydroxyvitamin D concentrations (25[OH]D) below 30 ng/mL. In patients with chronic kidney disease, 25(OH)D levels should exceed 40 ng/mL, according to the Endocrine Society.

VITALE Study

The 536 patients were randomized to cholecalciferol — either 12,000 IU or 100,000 IU — every other week for 2 months, and monthly thereafter for 22 months. They were then followed for 24 months.

During the 22-month maintenance phase, the low dose was equivalent to about 400 IU/day and the high dose was equivalent to about 3300 IU/day.
At baseline, 25(OH)D levels were similar in the low- and high-dose groups (19.2 vs 20.2 ng/mL), as was daily calcium intake.

The primary objective of the study was to evaluate the effect of the two doses of cholecalciferol on a composite end point of diabetes, major arterial coronary events, de novo cancer, and death.

At 24 months, 25(OH)D levels were significantly higher in the high-dose group than in the low-dose group (43.1 vs 25.1 ng/mL; P < .0001).

However, there was no difference in the number of composite end-point events in the high- and low-dose groups (15% vs 16%).

"Importantly, the incidence of each item in the primary end point was not significantly different between the two groups," Courbebaisse reported.

There were also no significant differences in infection rates between the high- and low-dose groups (51% vs 47%) or in acute rejection episodes (3% vs 2%). And rates of graft loss were identical in the two groups, at 0.37%.

However, the risk for symptomatic fracture was significantly lower in the high-dose group than in the low-dose group (1% vs 4%; odds ratio, 0.24; P = .02).

Serum parathyroid hormone concentrations decreased from baseline to month 24 in the high-dose group (77 vs 71 pg/mL; P < .05), but remained stable in the low-dose group throughout the study period (77 vs 78 pg/mL).

There were also no differences in the incidence of hypercalcemia in the high- and low-dose groups (17% vs 13%), the incidence of hyperphosphatemia (5% vs 4%), or in the urinary calcium to creatinine ratio.

"After renal transplantation, high doses of cholecalciferol are well tolerated and they do not increase the risk of extraskeletal complications, compared with the minimally recommended intake of vitamin D for the general population," said Courbebaisse.

"Recommendations should be rewritten, as we now know, thanks to this study, that to obtain sufficient vitamin D levels after renal transplantation, we obviously have to increase the dose," she said.

"More broadly," Zoccali added, "we see, yet again, that other benefits for vitamin D seen in observational studies are not reflected when supplementation is tested in randomized controlled trials."

Courbebaisse and Zoccali have disclosed no relevant financial relationships.

European Renal Association–European Dialysis and Transplant Association (ERA-EDTA) 56th Congress. Presented June 14, 2019.



https://www.medscape.com/viewarticle/914887
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  #1708   ^
Old Fri, Jun-28-19, 01:55
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Quote:
University of Glasgow
27 June, 2019

Low UVB exposure in pregnancy linked with higher risk of learning disabilities

Too little sunlight – and specifically UVB exposure – in pregnancy has been linked with a higher risk of learning disabilities.

In a new study looking at more than 422,500 school-age children from across Scotland, researchers found that low UVB exposure during pregnancy was associated with risk of learning disabilities.

UVB exposure from sunlight is linked to the production of the essential nutrient vitamin D in the body.

Publishing their results in the journal Scientific Reports, University of Glasgow researchers linked sunshine hours data from the Met Office with the month in which children were conceived. They found that there was a statistically significant relationship between lower UVB exposure over the whole of pregnancy and the risk of learning disabilities.

The relationship was specific to UVB (not UVA) suggesting that the effect of sunlight was likely to be working via production of vitamin D.

During the antenatal period, the foetus undergoes rapid development and growth, making it susceptible to environmental exposures, with the potential of long-term consequences. Maternal UVB exposure promotes the production of vitamin D, which is important for normal brain development of a foetus.
The researchers also found a slightly stronger relationship with low UVB exposure in the first trimester, suggesting that early pregnancy may be the most vulnerable to the effects of insufficient UVB.

As a result of low levels of UVB radiation from sunlight, vitamin D deficiency is common over winter months in high latitude countries such as Scotland. With Scottish residents twice as likely to be vitamin D deficient than people living in other parts of the UK.

Professor Jill Pell, Director of the University of Glasgow’s Institute of Health and Wellbeing and lead author of the study, said: “Learning disabilities can have profound life-long effects on both the affected child and their family. The importance of our study is that it suggests a possible way to prevent learning disabilities in some children. Clinical trials are now needed to confirm whether taking vitamin D supplements during pregnancy could reduce the risk of learning disabilities.”

Of the 422,512 schoolchildren included in the study, 79,616 (18.8%) had a learning disability, 49,770 (23.1%) boys and 29,846 (14.4%) girls. The percentage of children with learning disabilities varied by month of conception, ranging from 16.5% among children conceived in July, to 21.0% among those conceived in February, March and April.

Dr Claire Hastie, who did the analysis, said “Our study linked routinely collected health and education data with environmental data enabling us to study a very large number of children in a way that would not be possible using traditional methods.”

The study, ‘Antenatal exposure to solar radiation and learning disabilities: Population cohort study of 422,512 children’ is published in Scientific Reports. The work was funded by HDR UK (Health Data Research UK).




https://www.gla.ac.uk/news/headline_653914_en.html


Link to paper:

Antenatal exposure to solar radiation and learning disabilities: Population cohort study of 422,512 children



Quote:
From The Times
London, UK
28 June, 2019

Vitamin D-Day

Ministers must act on research showing link between poor health and lack of sunlight


The facts about vitamin D and good health have long been known. What has emerged only over the past decade is the close link between a deficiency of that vitamin and the lack of sunlight in certain parts of the country. Ten years ago The Times reported on statistics that showed a clear correlation between low exposure to sunlight and high incidences of a range of diseases, such as multiple sclerosis, heart disease and diabetes. They were particularly prevalent in the west and north of Scotland, where weather patterns meant there were significantly fewer hours of sunshine than on the east coast of the UK.

Yesterday’s report from the University of Glasgow emphasises the vitamin D connection — this time among children with learning difficulties. In a study involving more than 400,000 children, researchers looked at the intensity of ultraviolet rays which help the body to produce vitamin D and found that UVB, a component of sunlight, appeared to be particularly important among pregnant mothers. Where levels of UVB were lowest in Scotland — commonly, in the west — mothers were twice as likely to have a child with at least one learning disability, compared with those pregnant when exposure to the sun’s rays was at its highest.

Jill Pell, who led the study, said learning disabilities could have profound lifelong effects on the child and their family and concluded: “The importance of our study is that it suggests a possible way to prevent learning disabilities in some children. Clinical trials are needed to confirm [if] taking vitamin D supplements during pregnancy could reduce the risk of learning disabilities.”
When, a decade ago, The Times first disclosed the statistics on weather patterns and incidences of disease, carried out by the health expert Oliver Gillie, it argued strongly that there was a case for a government campaign to include vitamin D in certain basic foods as one way of combating Scotland’s appalling health record. Lip service was paid to the idea and, in 2012, Shona Robison, the health secretary, did go so far as to recommend vitamin D for pregnant mothers. It fell well short of an active programme, however.

Professor Pell is right to recommend supplements but to make this an effective national programme food labelling might be an effective means as well. The death of Natasha Ednan- Laperouse after eating a sandwich containing sesame, to which she was allergic, has ushered in Natasha’s Law, which will require all foods to be clearly and effectively labelled if they contain potentially harmful ingredients.

There is no reason why this approach should not be adopted for more positive reasons: to show which foods are high in vitamin D. Doctors’ surgeries, nurseries, schools, colleges and other venues could be required to highlight the health advantages of such foods and their vitamin D benefits. Already we know that fish, eggs, some breakfast cereals, yoghurts and orange juice, have a high vitamin D content; fortified milk is also rich in the vitamin, and could be promoted in supermarkets.

The success of health legislation in Scotland, such as the smoking ban and the minimum pricing of alcohol, demonstrate that a determined government can have an effect on health statistics if it can be convinced that there is scientific evidence to back it. That evidence has been provided by the Glasgow university research. All that is now required is the will to translate it into action.



https://www.thetimes.co.uk/article/...d-day-mlmj2cw3j
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Can Vitamin D Prevent Asthma Attacks?

https://www.news-medical.net/health...ma-Attacks.aspx

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Old Tue, Jul-02-19, 04:32
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Low vitamin D at birth raises risk of higher blood pressure in kids

https://www.sciencedaily.com/releas...90701144254.htm

Quote:
Vitamin D deficiency from birth to early childhood was associated with an increased risk of elevated systolic blood pressure during childhood and adolescence. The study findings suggest that vitamin D screening and supplementation in pregnancy and early childhood could prevent or reduce the risk of elevated blood pressure later in life.
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