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  #1   ^
Old Thu, Dec-06-18, 02:41
Demi's Avatar
Demi Demi is offline
Posts: 22,045
 
Plan: LCHF/IF
Stats: 217/192/160 Female 5'10"
BF:
Progress: 44%
Location: UK
Default Obesity Could Be Prevented by Blocking Single Gene

Quote:
Obesity Could Be Prevented by Blocking Single Gene

Studies in mice by an international team of scientists suggest that inhibiting a single gene could combat obesity and related metabolic disorders by allowing people to eat as much as they want without putting on weight. When the Flinders University-led team deleted the gene, known as regulator of calcineurin 1 (RCAN1), in mice fed a high-fat diet (HFD), the animals didnít put on weight because their whole body metabolic rate increased.



https://www.genengnews.com/news/blo...u-can-eat-pill/
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  #2   ^
Old Thu, Dec-06-18, 08:53
GRB5111's Avatar
GRB5111 GRB5111 is offline
Posts: 2,461
 
Plan: Ketogenic (LCHFKD)
Stats: 227/186/185 Male 6' 0"
BF:
Progress: 98%
Location: Herndon, VA
Default

Hmmm, I eat a high-fat diet (relatively speaking), and I don't put on weight. Somehow, I must have turned off my obesity gene . . . .
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  #3   ^
Old Thu, Dec-06-18, 09:41
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mike_d mike_d is offline
Grease is the word!
Posts: 8,364
 
Plan: PSMF/IF
Stats: 236/181/180 Male 72 inches
BF:disappearing!
Progress: 98%
Location: Alamo city, Texas
Default

Quote:
Originally Posted by GRB5111
Hmmm, I eat a high-fat diet (relatively speaking), and I don't put on weight. Somehow, I must have turned off my obesity gene . . . .
Yes, surprising even some PhD's think "of course, fat makes you fat."

As regards rodents; the smaller the animal the higher its MBR.

That being said, "knocking out a gene" is rather trivial now using Cas9, there are even DIY experiment kits for sale on Amazon. Tags are available now for $45. Target Gene editing in an adult human is still difficult and experimental, requiring a modified vector such as an adenovirus. It's not FDA approved yet in the US, even though a few people are doing it.
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  #4   ^
Old Thu, Dec-06-18, 10:34
s93uv3h s93uv3h is online now
 
Plan: Atkins & IF
Stats: 000/014.5/015 Male 5' 10"
BF:
Progress: 97%
Default

Quote:
Originally Posted by mike_d
"of course, fat makes you fat."
or inflamed - re: omega 3 / omega 6 ratio.
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  #5   ^
Old Thu, Dec-06-18, 11:43
teaser's Avatar
teaser teaser is online now
Senior Member
Posts: 13,104
 
Plan: mostly milkfat
Stats: 190/152.4/154 Male 67inches
BF:
Progress: 104%
Location: Ontario
Default

There's no question a high fat diet makes people fat. The question is, which one?
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