I started out on 1/2 a grain of Armour. I'm now up to 2 grains and feel so much better. I've only ever taken it in the morning. I don't have any afternoon slumps so I think it's working well for me this way. I'd try taking it all in the am and if you feel slumpish then maybe split it. On the way up, I'd feel good for a few days or a week and then start feeling crappy again. My doctor had me increase by 1/4 - 1/2 grain at a time. Just be aware that you may have some ups and downs until you're at an optimized level.