Originally Posted by teaser

Not saying choline's not good for the brain. But higher quality evidence doesn't give lower quality evidence a bump up in quality. More like it makes it less relevant.

There's another line that's interesting to me, a fellow looking at a mouse model for schizophrenia that's caused by a deficiency of nicotinic receptors. There are some studies looking at nicotine therapy for schizophrenia... anyways, in the mouse model, making sure the baby animals (and the mother) get lots of choline seems to be protective. They've done one study in humans--they're not allowed to have a choline-deficient group of course, but there's no reason to think that extra choline will be harmful, TMAO-phobes aside. That's shown some promise in intellectual development at two years, but they won't know if it decreases rate of schizophrenia until the late teens to mid-twenties.