Hi all! I have unsuccessfully tried all anti-inflammatories, anti-spasmotics and narcotics (and Lyrica) for my Fibro and the meds others listed for my Osteo and muscular pains. I currently need both of my knees replaced. A friend told me about the Guaifenesin helping my Fibro and I immediately started reading up on it. I then immediately started taking it and after only 2 months (along with a very low carb diet), I can walk and move about it without screaming in pain. If anyone says this is all psychological - well then, okay...as long as I can walk and move, I don't care what anyone says. It works.