Hello Faithleigh i too am on mtx and have been injecting for 1.5 yrs at 20mg/week. Like you say the next day is a downer and today is my day. I just got out of bed for the day and I got into bed last night and now its next day evening. I could not get up to even eat so when I did get up i had to get something in pretty fast; I also have hypoglycemic issues. It is a struggle for sure. My Vit D is very very good and always has been so I do tons of other things to try and help myself along under Rheumy doc supervision.