Wed, Apr-24-19, 05:19
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Senior Member
Posts: 19,214
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Plan: atkins, carnivore 2023
Stats: 200/211/163
BF:
Progress: -30%
Location: Massachusetts
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https://www.sciencedaily.com/releas...90422151015.htm
Quote:
The test uses a urine sample to check concentrations of a type of sugar -- glycosaminoglycans -- that ordinarily coat cells lining blood vessels and other surfaces inside the body. In septic shock, the body sheds fragments of these sugars, and the team found that higher concentrations portend death. The test is used in clinical settings, and the insight has helped doctors search for more effective therapies.
Their next step tested whether a link exists between the sugars and mental aging associated with septic shock. Research published in the February edition of the Journal of Clinical Investigations showed that, during septic shock, fragments of the sugar heparan sulfate crossed the blood-brain barrier and entered the hippocampus, a region of the brain critical to memory and cognitive function. Evidence indicated that the heparan sulfate might be binding with brain-derived neurotrophic factor (BDNF), which is critical to hippocampal long-term potentiation, a process responsible for spatial memory formation. The researchers also found that presence of an enriched heparan sulfate in the blood plasma of septic patients upon admission to an intensive care unit predicted cognitive impairment detected 14 days after discharge.
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