Active Low-Carber Forums - View Single Post - Dr. Jason Fung. The Obesity Code

Quote:

Originally Posted by CityGirl8

I thought you might be interested in this talk from Dr. Nadir Ali on autophagy at the recent Ketofest. His talk starts at 47:00 and he's got a couple of slides on "when does autophagy start" at about 1:12:40.

In short, he's saying that it depends on a number of factors. If you are older, obese, sedentary, and eat a SAD diet it might take two to three days. If you are younger, leaner, more active, have good cholesterol, and eat a LCHF diet, then it might take 24 hours. You might need EF if you have severe health concerns to address like Alzheimer's, inflammation and high blood pressure, and severe insulin resistance.

He does mention a mouse study as well as some results from exercise related studies on autophagy in humans.

I still don't think it really answers your question definitively with a specific scientific study or two in humans, though.

Thanks, CG8. This is plausible and is consistent with Fung's observation. I agree that those who are low or very low carb likely experience autophagy sooner, and that it's a rising curve given the duration of a fast and the WOE of the one fasting. Yes, specific research will be enlightening, as most of what we have currently is anecdotal. I believe autophagy starts for me anywhere from 16-20 hours from the my last meal or when my glycogen stores are depleted. I know when I've done multi-day IFs, I no longer have any hunger after the 2nd day, and I'm also likely in full blown autophagy by that time. Be great to have confirming human research.