Thu, Feb-13-20, 12:21
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Senior Member
Posts: 19,301
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Plan: atkins, carnivore 2023
Stats: 225/224/163
BF:
Progress: 2%
Location: Massachusetts
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WOW, this theory is amazing. Perhaps it is not just carbs that contribute to obesity but the decades of push to eat seed oils.
Quote:
My early hypothesis was that PUFA somehow drove the increase in obesity and maybe the fall off of saturated fat intake contributed.
In other words, maybe PUFA is driving the obesity epidemic while saturated fat is protective. So, I started looking for a biochemical or physiological mechanism that could explain this.
I came across the work of Peter Dombromylskyj, (see his Proton Series in his Hyperlipid blog) who had gone back the basic biochemistry of fat metabolism and noticed that saturated fat increased the production of FADH2 while PUFA decreased it. So, the ratio of the two, the FADH2/NADH ratio, may act as a switch to control the storage of fat. As the ratio goes up—more FADH2 to NADH—the storage of fat goes down.
If this were true, then it would help explain the enormous increase in obesity since around 1980. Since then—thanks to the widespread fear of saturated fat—we’ve all been reducing saturated fat and replacing it with PUFA.
By advocating the substitution of PUFA, provided mainly in the form of industrial seed oils, for saturated fat, which we have all eaten for millennia, in a misguided attempt to reduce the rate of heart disease, the nutritional authorities unwittingly set us up for the massive obesity epidemic we’re now in the midst of.
A diet high in PUFA, by the decrease in production of FADH2, inhibits the rate of RET, allowing the fat cells to continue to take up calories beyond a certain set point. Adding saturated fat increases the RET and signals that the fat cells are full.
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