Thu, Apr-11-19, 09:21
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Senior Member
Posts: 19,293
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Plan: atkins, carnivore 2023
Stats: 225/224/163
BF:
Progress: 2%
Location: Massachusetts
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Biochemistry of energy use in layman's terms.
https://feinmantheother.com/2016/11...ies-might-help/
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We found that if you grow cancer cells in culture, ketone bodies will inhibit their growth and the amount of ATP that they can generate.
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More explanation of energy use by cells--
https://feinmantheother.com/2016/12...warburg-effect/
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if we grow cancer cells in culture, acetoacetate (one of the ketone bodies) will inhibit their growth and will reduce the amount of ATP that they can generate. Normal cells, however, are not inhibited by ketone bodies and the cells may even be using them. Our working explanation is that the ketone bodies are inhibiting the cancer cell through the Randle cycle. Now, normal cells can maintain energy, that is compensate for the Randle cycle, by running the TCA cycle (in fact, that is the purpose of the Randle cycle: to switch fuel sources). The cancer cells, however, have some kind of defect in aerobic metabolism and can’t compensate. How does this happen? That’s what we’re trying to find out but we have a good guess.
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THses three blogs were posted in 2016.
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