Thu, Jan-28-16, 18:27
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Senior Member
Posts: 6,498
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Plan: VLC, mostly meat
Stats: 202/200/165
BF:
Progress: 5%
Location: Montreal, Quebec, Canada
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Quote:
Originally Posted by Kristine
I just had to google this, because I couldn't believe you could be allergic to meat, when we're basically made of meat. From wikipedia:
I think I got confused because a lot of people use the word "meat" to refer exclusively to "beef." Although I use the specific words also, like poultry/veal/venison/pork/etc, "meat" to me generally means "my food that had a face."
I'd mourn if I was afflicted with this tick bite and allergy, but at least I could still indulge in chicken, turkey, eggs, and seafood.
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Well, also from Wiki, we got this from the link to alpha-gal:
Quote:
Galactose-alpha-1,3-galactose, commonly known as alpha gal, is a carbohydrate found in most organisms' cell membranes. It is not found in primates, including humans, whose immune systems recognize it as a foreign body and produce xenoreactive immunoglobulin M antibodies, leading to organ rejection after transplantation.[1] It has also been suggested to play a role in an IgE-specific allergic response to some meats.[2] Recent studies are showing increasing evidence that this allergy may be induced by the bite of the lone star tick (Amblyomma americanum)[3] in North America and the castor bean tick (Ixodes ricincus) in Sweden.
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The immune system recognizes it. It recognizes it when it enters the bloodstream from that tick's bite. But if there's an allergic reaction to meat when we eat it, it also recognizes it before it enters the bloodstream. So, the allergy cannot be solely attributed to alpha-gal alone, there must be some other substance that first enters the bloodstream to cause the initial immune response, but then remains in the bloodstream or tissues to cause further immune response that does not otherwise occur before the initial tick bite. Maybe the substance that remains is a bacteria or virus or some other live pathogen that reacts to alpha-gal, and it is this reaction that triggers the allergic immune response. At first I thought alpha-gal would need to enter the bloodstream from the gut to cause the reaction, but it's not necessary if the live pathogen has infected the gut tissue. Its reaction to alpha-gal would propagate on both sides of its cell host, so both the gut and the bloodstream.
There's this idea that a substance or a cell does not need to be the primary target for the immune system to fight it. With MS for example when treated with antibiotics in some protocols, liver cells can be destroyed. One possibility is that the antibiotics destroy those cells directly, but the other more likely possibility is that the liver cells are infected with the pathogens, and when the antibiotics reach them, they destroy the pathogen and this in turn causes the liver cells to suicide. Anyways, for alpha-gal, if the immune system can't recognize the pathogen directly, it could still fight it if it infected tissues and if it reacted to alpha-gal and if the immune system recognized this reaction. Well, it does recognize alpha-gal, it does fight it, but somehow it does it to the detriment of the host after the initial tick bite, and to the benefit of the host before the initial tick bite. Something's different, and it's not the immune system.
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