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  #1   ^
Old Wed, Mar-21-12, 04:00
Demi's Avatar
Demi Demi is offline
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Default If your vitamin D levels are low, what’s a useful starting dose?

From Dr Briffa's blog:


Quote:
21 March, 2012

If your vitamin D levels are low, what’s a useful starting dose?

I was talking with someone yesterday about his vitamin D levels. He had these tested recently and found these came in at 15 ng/ml (about 38 nmol/l). Personally, I like vitamin D levels to be maintained in the region of 50 ng/ml. So, I suggested he take 5,000 IU of vitamin D3 for three months after which he’ll re-check his levels.

He asked me how I arrived at a dose of 5,000 IU. Good question. This ‘starting dose’ is actually based on my experience. It’s this sort of level of intake that I find can get vitamin D levels up from quite low levels to more optimal levels in a reasonable amount of time (say, a couple of months).

When I started supplementing myself with vitamin D (starting levels, 15 ng/ml), I thought I was being gung-ho by taking 2,000 IU a day. I soon realised this was an inadequate dose for my requirements. I now take about 5,000 IU during the summer and about 7,500 IU per day during the rest of the year.

Later in the day, I decided to see if there was any recent science in this area. I found a study published just a few days ago in which individuals with vitamin D deficiency were treated with either 2,000 or 5,000 IU vitamin D for 3 months [1]. All individuals started with vitamin D levels at or below 20 ng/ml.

At the end of the study, those taking 2,000 IU saw their vitamin D levels increase by about 80 per cent, while those on 5,000 IU had their levels more than treble on average. At the end, 45 per cent taking 2,000 IU had achieved levels of 30 ng/ml or more, compared to 93 per cent taking 5,000 IU.

No-one in the study suffered from adverse symptoms or raised blood levels of calcium (a theoretical risk of high vitamin D levels).

This study appears to provide some support for the idea that those with low vitamin D levels might start with a dose in the order of 5,000 IU. How people respond to supplementation is, however, quite variable, which is why I advise monitoring blood vitamin D levels.

Previously I have used testing provided by Grass Roots for Health and Vitamin D3 World. However, here in the UK, I’ve recently started to use this service out of City Hospital in Birmingham which seems to be very good (and economical). See here.

References:

1. Diamond T, et al. Effect of oral cholecalciferol 2,000 versus 5,000 IU on serum vitamin D, PTH, bone and muscle strength in patients with vitamin D deficiency. Osteoporos Int. 2012 Mar 16. [Epub ahead of print]
http://www.drbriffa.com/2012/03/21/...-starting-dose/
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  #2   ^
Old Wed, Mar-28-12, 06:52
Zuleikaa Zuleikaa is offline
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I think 5,000 IU is way too low. IMO, 5,0000 IU/day is a maintenance dose as there have been studies that the human body uses between 5,000-7,000 IU/day of D3.

First you have to "fill the hole", then you can maintain.
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  #3   ^
Old Wed, Mar-28-12, 08:08
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aj_cohn aj_cohn is offline
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Default

The best way to determine your vit. D needs is to get a 25 OHD test for a baseline on your vit. D status. Then take enough to get it to between 60 and 70 (U.S. test values) 3 months later. Then back off a bit for maintenance. For me, that process yielded a regimen of 6,000 IU daily for 3 months to get to the normal range, then 4,000 IU daily.

Don't forget to get enough magnesium, or vit. D can make you ill.

Last edited by aj_cohn : Wed, Mar-28-12 at 08:14.
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  #4   ^
Old Wed, Mar-28-12, 08:16
Zuleikaa Zuleikaa is offline
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Quote:
Originally Posted by aj_cohn
The best way to determine your vit. D needs is to get a 25 OHD test for a baseline on your vit. D status. Then take enough to get it to between 60 and 70 (U.S. test values) 3 months later. Then back off a bit for maintenance. For me, that process yielded a regimen of 6,000 IU daily for 3 months to get to the normal range, then 4,000 IU daily.

Don't forget to get enough magnesium, or vit. D can make you ill.

And you live in California. The Bay area even though more cloudy than some CA locales gets a lot more sun than places further north.

I agree that people should get tested before and 3 months after supplementing.
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  #5   ^
Old Wed, Mar-28-12, 08:23
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aj_cohn aj_cohn is offline
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You're right, Zuleikaa. I hope I didn't imply that the amounts I take are appropriate for everyone.
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  #6   ^
Old Wed, Mar-28-12, 08:32
Zuleikaa Zuleikaa is offline
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Quote:
Originally Posted by aj_cohn
You're right, Zuleikaa. I hope I didn't imply that the amounts I take are appropriate for everyone.


No, you didn't.

I was just pointing out, without being explicit, that you live in California and it still took you more than 5,000 IU/day to bring your values up.

Someone living further north, or someone who doesn't get much sun, or someone who is darker skinned, or someone who is very pale, or someone who is older, or someone who is heavier, or someone who already has deficiency symptoms will require a higher dose to reach normal/optimal vitamin D levels.

You are right...vitamin D supplementation needs are very individual. One sized dose does not fit all, lol!!

Last edited by Zuleikaa : Wed, Mar-28-12 at 08:41.
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  #7   ^
Old Wed, Mar-28-12, 08:51
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aj_cohn aj_cohn is offline
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Default

Despite the fact that I live in CA, I'm mostly an indoors person. I rarely get out during the times of day where it's possible to absorb UV from the sun (10–2, during the summer). So, where you spend your time is also a factor to consider for vit. D supplementation.
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  #8   ^
Old Wed, Mar-28-12, 09:03
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daisy0610 daisy0610 is offline
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Default

Very interesting info! My levels are always low when I do my annual bloodwork so my Dr. told me to take one 1,000 IU supplement per day. I am curious when I am retested this year to see if that has made much of an improvement, or if I should be increasing my dosage.

Thanks for the info! :daisy:
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  #9   ^
Old Wed, Mar-28-12, 09:23
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ajewett07 ajewett07 is offline
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This might sound stupid but how does low vit. D effect a person's weight or their ability to lose weight? Mine is low as well...
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  #10   ^
Old Wed, Mar-28-12, 09:25
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Nancy LC Nancy LC is offline
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I don't think they really know, but it can affect your health a whole lot. Heart disease, diabetes, and cancer seem to go along with low D3 levels.
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  #11   ^
Old Wed, Apr-04-12, 13:33
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Demi Demi is offline
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Quote:
From the Vitamin D Council:

Comparing 2,000 IU/day vs. 5,000 IU/day vitamin D supplementation

March 29, 2012 -- John Cannell, MD


Dr. Terry Diamond and colleagues of St. George’s Hospital in New South Wales just published the first head-to-head comparison of 5,000 IU/day to 2,000 IU/day. Remember, the Food and Nutrition Board says 4,000 IU/day is the upper limit, but Dr. Diamond knows the pharmacology of vitamin D well enough to know that quite a few people will still have inadequate levels at 4,000 IU/day.

He recruited 30 patients with vitamin D levels less than 20 ng/ml and put half on 5,000 IU/day and half on 2,000 IU/day for three months. He measured a number of things, the most important of which was muscle strength.

Diamond T, Wong YK, Golombick T. Effect of oral cholecalciferol 2,000 versus 5,000 IU on serum vitamin D, PTH, bone and muscle strength in patients with vitamin D deficiency. Osteoporos Int. 2012 Mar 16.

After 3 months of 2,000 IU/day the vitamin D levels averaged 30 ng/ml (75 nmol/L), meaning about half the patients were still vitamin D deficient. Not so with the 5,000 IU/day group. The average vitamin D level was 45 ng/ml (114 nmol/L), right in the “natural range.” In addition, 93% of the patients had levels higher than 30 ng/ml compared to the 2,000 IU/day group, where only 45 % had levels above 30 ng/ml. Remember, one of the problems with daily dosing is that you must rely on the patient to take their medication. As an old GP, I am here to tell you not all patients take their meds; the ones that get me are the ones who look me straight in the eye and tell me something I know is not true.

In Dr. Diamond’s well-designed study, changes in grip strength compared to baseline were very significant, while the improvements in timed tests of sitting to standing and the 6-meter walk test also improved, but not significantly. What surprised me was that the improvements did not vary with dosage. That is, the 2,000 IU/day had the same improvements in grip strength as did the 5,000 IU/day, meaning muscle strength improvements are the most dramatic at changes in lower ranges of vitamin D levels. By that, I mean if your level is 5 ng/ml to start out and you get to up to 20 ng/ml, your percentage improvement in muscle strength will be much more dramatic than someone who went from 20 to 35 ng/ml.

I am glad to see Australians using daily dosing of vitamin D. Many of the “Stoss” doses, 100,000 IU/month or 600,000/year are not physiological, and are dangerous. Vitamin D was made every day in the skin of our ancestors and we should strive to replicate such dosing schedules. How much do we need? To quote Dr. Diamond, “This study demonstrates that the administration of oral vitamin D at 5,000 IU daily is superior to 2,000 IU daily for 3 months to treat mild to moderate vitamin D deficiency.”
http://blog.vitamindcouncil.org/201...upplementation/
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  #12   ^
Old Fri, Mar-22-13, 16:44
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JEY100 JEY100 is online now
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In another article on Vitamin D in Dr. Briffa's blog, he provided a link to a chart on how to dose Vitamin D when you know your baseline value, as well as the level to which it should be raised.
http://grassrootshealth.net/media/i...arts-single.pdf
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  #13   ^
Old Sat, Mar-30-13, 16:42
black57 black57 is offline
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I can tell you from experience 4,000 IUs would do noting for me.
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  #14   ^
Old Tue, Apr-09-13, 14:12
cindy_cfid cindy_cfid is offline
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Default everything I've found about vitD

Research published by Grassroots Health from the D*Action study shows that 97.5% of the adult population needs to take 9,600iu of vitamin D per day in order to elevate their levels above 40ng/ml, which they believe is the absolute minimum for disease prevention. 14,100iu/d is needed to get 97.5% of the population above 50 ng/ml Universal intake of up to 40,000 IU vitamin D per day is unlikely to result in vitamin D toxicity.

Your vitamin D level should never be below 32 ng/ml, and any levels below 20 ng/ml are considered serious deficiency states, increasing your risk of as many as 16 different cancers and autoimmune diseases like multiple sclerosis and rheumatoid arthritis, just to name a few.

They found that the body does not reliably begin storing cholecalciferol in fat and muscle tissue until 25(OH)D levels get above 50 ng/ml (125 nmol/L). That is, at levels below 50 ng/ml (125 nmol/L), the body uses up vitamin D as fast as you can make it, or take it, indicating chronic substrate starvation—not a good thing. 25(OH)D levels should be between 50–80 ng/ml (125–200 nmol/L), year-round.

http://www.vitamindcouncil.org/heal...deficient.shtml

Vitamin D3 deficiency has become an epidemic, probably because people are washing daily. If you wash skin exposed to the sun within 48 hours, you wash off the oils where the vitamin D production starts. In northern latitudes (above that of Atlanta, Georgia) the sun is at too low an angle for half the year to provide sufficient UV radiation. If even available, UVB rays are only accessible while the sun is directly overhead. Most people need to take vitamin D, especially seniors, as the ability to synthesize vitamin D in the skin declines with age.

With exposure to sunlight in the summer, the body can generate up to 20,000iu of vitamin D per hour with no ill effects. In addition, no adverse effects have been seen with supplemental vitamin D intakes up to 10,000 IU daily.

Vitamin D3 is not a vitamin at all but a necessary hormone that effects the immune system, bones & nearly every aspect of health. Having low Vitamin D levels greatly increases risk of cancer, heart disease, diabetes, MS & being deficient can create or greatly exacerbate health problems. Many researchers claim that optimized vitamin D levels are more effective than a flu shot in preventing viral infections.

Always take your vitamin D with a fat-containing meal to ensure absorption.

http://www.drweil.com/drw/u/QAA4006...-Vitamin-D.html

The prescription vitamin D supplements are the wrong type (ergocalciferol - vitamin D2). As warned by the National Institute of Health -

http://www.ncbi.nlm.nih.gov/pubmed/17023693

Luckily you can buy vitamin D3 (cholecalciferol) over the counter and the upper limits are extremely high. U.S. RDA are much too low. Current recommendations from researchers are for 35iu per pound - a 150# person needs minimum of 5250iu per day & the rda is 400iu. This amount is for minimal needs and does not replenish depleted stores.


http://curezone.com/forums/fm.asp?i=1560518#i
http://articles.mercola.com/sites/a...-the-Truth.aspx





Vitamin D deficiency may contribute to the wide set of disorders associated with metabolic syndrome (syndrome X), as well as to PCOS. In a study published in 2004, the authors saw a 60% improvement in insulin sensitivity in healthy, vitamin D replete adults

http://www.womentowomen.com/healthy...n/vitamind.aspx



Dr. Joe Prendergast, an endocrinologist /diabetologist has managed over 1500 diabetic patients and, in the last decade, not one of his patients has had a stroke or heart attack. Only one has even been hospitalized! His secret—50,000 units of Vitamin D3 daily. Dr. Joe further reports:

* Reversal of advanced coronary disease
* Reversal of advanced lung disease
* Cure of multiple sclerosis
* Cure of amotrophic lateral sclerosis
* Regression of rheumatoid arthritis
* Improvement in allergies
* Control of many cancers
* Reversal of osteoporosis
* Prevention of influenza
* Cure of depression & other mental disorders
* Hashimoto’s hyperthyroidism

In summary, the evidence for safety and remarkable efficacy of Vitamin D3 suggests that virtually ALL adults should probably take 50,000 units of D3 daily. This is certainly true for those with virtually any illness.

http://enews.endocrinemetabolic.com...y-diseases.html


Order the Correct Test. There are two vitamin D tests -- 1,25(OH)D and 25(OH)D.
25(OH)D also called 25 hydroxy is the better marker of overall D status.
25(OH)D test level - between 50–80 ng/ml (125–200 nmol/L), summer and winter
http://www.directlabs.com/
Vitamin D, 25 Hydroxy regularly $59



The cheapest source I've found for vit D3 -

http://www.vitacost.com/Referee?wls...ralCode=2287858

preferred recommendation - Country Life Vitamin D3 in MCT -- 5000 iu - 200 Softgels $8.62
2nd option - Vitacost Vitamin D Drops -- 2000 IU 900 servings - 1 fl oz = 365 days at 4960 iu $9.99
cheapest - 10,000 iu vit D for 365days $16.99
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  #15   ^
Old Tue, Jun-18-13, 16:26
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Atrsy Atrsy is offline
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I take 10,000 IU of Vit D3 a day. Last summer my level was 85 ng/ml and my doctor thought it was too high and wanted to recheck it in 6 months. That put me into winter and my level had gone down to 59 ng/ml. The sun took me up to where I wanted to be, but being inside brought it way down without changing the dosage. So I would say that the time of year will also change your results. I still take the 10,000.
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