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  #16   ^
Old Thu, Aug-31-17, 15:18
TucsonBill's Avatar
TucsonBill TucsonBill is offline
Senior Member
Posts: 339
 
Plan: ≤ 20 carbs & IF
Stats: 292/235/170 Male 72 Inches
BF:
Progress: 47%
Location: Tucson, AZ
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One last thing I'll throw in here are some of the other possible positive side effects of the Farxiga that I found (in reading as much as I could about it). It does seem that some beta cells to have the ability to recover in some Type II diabetics:

https://www.diabetesselfmanagement....ells-be-healed/

The pancreases of diabetic mice, (how the heck do they find enough diabetic mice?), fed a LCHF diet AND and who were given SGL2 inhibitors recovered significantly more beta cell function than those on the LCHF diet alone in 4 just weeks:

http://www.diabetesincontrol.com/sg...l-preservation/

Hopefully, I wont be on these medications much beyond 4 weeks so maybe it will work to my benefit.
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  #17   ^
Old Fri, Sep-01-17, 03:19
JEY100's Avatar
JEY100 JEY100 is offline
Posts: 13,431
 
Plan: P:E/DDF
Stats: 225/150/169 Female 5' 9"
BF:45%/28%/25%
Progress: 134%
Location: NC
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Agree with Thud, we have wandered off the rapid weight loss ranch. If those supplements are heart related, you might ask on that forum, or nutrition/supplements or diabetes forum. Can also check the People's Pharmacy. https://www.peoplespharmacy.com/hea...artery-disease/ for trustworthy advice.
In general, good nutrition is the best medicine. Don't eat sugar or starch, but eat the salmon with some olive oil on a salad and you shouldnt need (usually expensive and unregulated) supplements. That heart check package sounds interesting if include a CAC plus other heart tests. Consider diet alone until have that baseline?

Last edited by JEY100 : Fri, Sep-01-17 at 04:23.
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  #18   ^
Old Fri, Sep-01-17, 05:21
teaser's Avatar
teaser teaser is offline
Senior Member
Posts: 15,075
 
Plan: mostly milkfat
Stats: 190/152.4/154 Male 67inches
BF:
Progress: 104%
Location: Ontario
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Quote:
Originally Posted by TucsonBill
One last thing I'll throw in here are some of the other possible positive side effects of the Farxiga that I found (in reading as much as I could about it). It does seem that some beta cells to have the ability to recover in some Type II diabetics:

https://www.diabetesselfmanagement....ells-be-healed/

The pancreases of diabetic mice, (how the heck do they find enough diabetic mice?), fed a LCHF diet AND and who were given SGL2 inhibitors recovered significantly more beta cell function than those on the LCHF diet alone in 4 just weeks:

http://www.diabetesincontrol.com/sg...l-preservation/

Hopefully, I wont be on these medications much beyond 4 weeks so maybe it will work to my benefit.


That second link looks like it deals with knockout mouse, those are genetically altered to produce less SGL2, that's a little bit different from being given inhibitors. That knockout will have been in place through embryonic development, weaning, etc

How they get so many diabetic mice is, they make them. There are various models--and the problem there is that there are various ways to make a mouse diabetic, and the relevance of a cure may depend on how relevant their model is to diabetes in humans.
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  #19   ^
Old Fri, Sep-01-17, 08:49
TucsonBill's Avatar
TucsonBill TucsonBill is offline
Senior Member
Posts: 339
 
Plan: ≤ 20 carbs & IF
Stats: 292/235/170 Male 72 Inches
BF:
Progress: 47%
Location: Tucson, AZ
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OK, well I had read an article that said studies had shown Farxiga, (and other SGL2 inhibitors), help restore beta cell function, without a specific reference, and I perhaps found the wrong study, here's another one regarding type II diabetics:

https://www.healio.com/endocrinolog...type-2-diabetes

And here is another that says that it can even help Type I diabetics:

http://www.diabetesincontrol.com/em...tic-beta-cells/

I do get the impression that many people here are totally sold on the low carb diets, I am too! I really wish I had listened to my doctor two years ago when I was pre-diabetic and had gone on Atkins. Instead, I took half measures, followed a half-assed ADA diet and drinking an herbal tea. It did "seem" to help. My continual weight gain stopped and over the past 2 years I went form 305 to 292. I know that's not much, but I "thought" I was making a little progress and was "shocked" to see how much higher my A1C had gone.

Low carb is definitely the way to go, I'm sold. I'm just not sold on throwing all the other medical science out the window or going against my doctors advice. I know he's a good doctor and I've been trusting him for over 30 years. I just wish I'd payed more attention two years ago.

EDIT: And just to reiterate, my doctor agrees that I should not be on the medications any longer than necessary and should get off them when they are no longer needed. I don't plan to be taking them much longer.

Bill
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  #20   ^
Old Fri, Sep-01-17, 09:48
teaser's Avatar
teaser teaser is offline
Senior Member
Posts: 15,075
 
Plan: mostly milkfat
Stats: 190/152.4/154 Male 67inches
BF:
Progress: 104%
Location: Ontario
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Reducing glucose reducing glucose-lipid toxicity in beta cells does make sense. Probably also, reduce fasting glucose, and there'll be a bigger difference between what the beta cells are exposed to fasted or fed, it sort of makes sense for beta cells to respond to a ten point increase in blood glucose if it's going from 80 to 90, but not so much if it's going from 200 to 210.

Your doctor sounds pretty good to me. It's that one mouse study I wasn't to certain about.
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  #21   ^
Old Fri, Sep-01-17, 18:38
~micha~ ~micha~ is offline
Registered Member
Posts: 83
 
Plan: Atkins
Stats: 182/165/125 Female 5'2"
BF:
Progress: 30%
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If you *do* need a cardiologist, I can (highly!) recommend Dr. Santiago Ramirez near Grant/Rosemont. I swear the man is worth his weight in gold!
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