I've been rolling my eyes over Jimmy Moore's latest cockamamie stunt for the last couple weeks. Apparently he interviewed Dr. Naiman recently and Dr. Naiman made the case for high protein. In the course of talking about his more reasonable usual approach to protein, sort of a 1:1 protein to fat ratio, that would be about two thirds of calories from fat, the rest mostly protein, he mentioned the protein sparing modified fast, which he calls 3:1 protein to fat. So Jimmy and his co-host on his new ketohack podcast accepted the unissued challenge and did that for a week.
Jimmy experienced hypoglycemia after his high protein meals. He did some interviews during the period, one with Dr. Fung, another with Dr. Nally, and also talked about this with various doctor-ish co-hosts of his podcasts. What got me stuck on this is that he kept explaining his hypos like this; he ate too much protein, his body turned it into glucose, this increase in glucose stimulated insulin, he experienced a hypo. Some of these professionals failed to address just how wrong this was, I thought Dr. Fung did a fair job. The fellow on the ketohack podcast actually did okay in my opinion, he got it more towards the insulin response being more directly caused by the protein, not some sudden increase in gluconeogenesis.
Nobody brought up free fatty acids, considering how often insulin reducing availability of free fatty acids is used to explain how insulin makes you fat, that seems a little weird.
Jimmy also reports "nutritional ketosis"level ketones during the experiment, and wonders why they didn't protect him from hypos. Remember that experiment from the 60s where people on an extended fast didn't experience hypoglycemic symptoms, even though insulin administered brought their blood glucose down to 20 mg/dl or lower? Take insulin after a 12 hour fast, enough to bring your glucose down to the 20's. Well, don't. The difference isn't just ketones, it's fatty acids, those starving people will still have high free fatty acids after the insulin dose, after a 12 hour fast and insulin, free fatty acids will be extremely low.
The most likely explanation to me is that this is like what happens with hypoglycemia from a sugar load, but with protein. You can't just look at the glucose, or the glucose and the ketones. Fasted people don't just have elevated ketones, they also have elevated free fatty acids--and even after an insulin injection bringing their blood glucose down to hypoglycemic levels, the free fatty acids will still be high. Contrast to excess insulin in a non-fasted person, free fatty acids will approach zero. Ketones can replace glucose, they can't replace glucose plus free fatty acids.
I've seen experiments with whey protein that look at the free fatty acid response. It's just like the response to glucose, there's an insulin response, free fatty acids get zonked at some point. Eat pure-ish protein or carbohydrate, the body's got this problem, free fatty acids need to decrease temporarily, this increases insulin sensitivity and facilitates the entry of the incoming nutrients into cells. There's always this problem of how well the system "anticipates" the necessary return of free fatty acids to the blood stream.
The hypo isn't quite the result of the insulin peak--it's a result of the mismatch, as the rate of influx of amino acids or glucose from the meal starts to diminish, insulin needs to go down and there needs to be that counterregulatory response to bring back free fatty acids, which will diminish insulin sensitivity. Even Jimmy's original fasting insulin of 15--suddenly drop his free fatty acids to zilch, and clamp his insulin at 15, and as a result of the increase in insulin sensitivity from the drop in free fatty acids, he'll be hypo, anybody would be.
This ties back to why I still think Jimmy should be not just keto, but the sort of "orthorexic" keto as he's described it, of his first year of nutritional ketosis. It isn't because that sort of strict, medical model ketogenic ratio diet keeps ketones elevated, or not just because--it's because eating that way, a meal will not decrease blood free fatty acid levels appreciably, ever.
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