Why Fat Angers the Immune System (New Scientist) : LC Research/Media Forum : Active Low-Carber Forums

#16 ^

Thu, Nov-05-09, 19:34

teaser

Senior Member

Posts: 489

Plan: Modified Pritikin
Stats: 190/167/160 Male 68 inches

BF:
Progress: 77%

http://neurologicalcorrelates.com/w...press-appetite/

Quote:

Consumption of dietary fats is amongst the most important environmental factors leading to obesity. In rodents, the consumption of fat-rich diets blunts leptin and insulin anorexigenic signaling in the hypothalamus by a mechanism dependent on the in situ activation of inflammation. Since inflammatory signal transduction can lead to the activation of apoptotic signaling pathways, we evaluated the effect of high-fat feeding on the induction of apoptosis of hypothalamic cells. Here, we show that consumption of dietary fats induce apoptosis of neurons and a reduction of synaptic inputs in the arcuate nucleus and lateral hypothalamus. This effect is dependent upon diet composition, and not on caloric intake, since pair-feeding is not sufficient to reduce the expression of apoptotic markers. The presence of an intact TLR4 receptor, protects cells from further apoptotic signals. In diet-induced inflammation of the hypothalamus, TLR4 exerts a dual function, on one side activating pro-inflammatory pathways that play a central role in the development of resistance to leptin and insulin, and on the other side restraining further damage by controlling the apoptotic activity.

I'm quoting a quote here. A drug that blocks TLR4 indiscriminately might not be such a good thing in the long run.

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#17 ^

Fri, Nov-06-09, 14:40

maxes

New Member

Posts: 1

Plan: lchf
Stats: 210/210/200 Male 192cm

BF:
Progress:

Quote:

Originally Posted by Hutchinson

.... The heavier you are the more proinflammatory cytokines you produce and the greater the inflammatory burden so the MORE vitamin D3 you require. Also the body senses how large your stores are and progressively wastes increasing amounts of D3 so it's more responsive the lower your 25(OH)D status and less responsive the higher your 25(OH)D level. That is why we know 10,000iu/daily is a safe upper limit even in sunny places.
......
You have to bear in mind that a naked body exposed to sunlight will make 10,000iu ~20,000iu fairly quickly. No one would suggest that our DNA is trying to kill us by producing that amount of D3. The skin only produces that amount because it senses that deficiency status. Once status rises it slows down production.

Thank you.

Vitamin D3 is a big miracle. Isn´t there enough Vit D in meat?

maxes

#18 ^

Fri, Nov-06-09, 15:05

capmikee

Senior Member

Posts: 3,611

Plan: Weston A. Price, GFCF
Stats: 165/140/132 Male 5' 5"

BF:?/12.7%/?
Progress: 76%

Location: Philadelphia

No, there's hardly any Vitamin D in meat. Even fish oil only has a small amount. Our bodies were designed to synthesize most of our Vitamin D during regular daily sun exposure without wearing clothes.

The omega-3s, Vitamin A and K2 in animal fat and organs will work synergistically with adequate Vitamin D, though.

#19 ^

Sat, Nov-07-09, 04:58

Hutchinson Hutchinson is online now

Senior Member

Posts: 1,510

Plan: Dr Dahlqvist's
Stats: 205/152/160 Male 69

BF:
Progress: 118%

Quote:

Originally Posted by maxes

Thank you.

Vitamin D3 is a big miracle. Isn´t there enough Vit D in meat?

maxes

capmikee is absolutely right but it is worth pointing out that vitamin d supplemenation for cows is now required as they spend more time indoors (well under cover in sheds) than in previous generations. So while it's likely free range outdoor raised animals may have an amount of vitamin d the amount of vitamin d generally available from industrially fatttened livestock with be negligible. UK milk because it isn't fortified artificially with Vitamin D only contains a trace of Vitamin D insufficient to be stated as a measurable amount.