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Originally Posted by Lere
Hutchinson, '"55ng 137.5nmol/l" ?
I think you meant to say ' 55ng/mL or 137.5nmol/L' .
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I think to intelligent people my meaning is clear enough.
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I'm interested in how much you take to attain and maintain such a level?[/url] I live at latitude 52 on a cloudy part of the country. So full body sun exposure is not possible for much of the year. I take 5000iu/d D3 and try to get 20~30mins full body sun exposure when the wind/cloud permits. I check my 25(OH)D twice yearly and have managed to keep it around 60ng for a couple of years now.
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"Maybe evolving naked living outdoors" would be significant if we maximized vitamin D production - but we don't. Like I said 'D' synthesis stops after 20 minutes of near full body exposure.
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Indeed that is why I suggest people restrict sun exposure to 20~30mins and then cover up go indoors cool off allow the d3 to absorb and then repeat with another 20~30minute session.
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And there are other limiting mechanisms. Think I'm making it up? You really need to read the references provided at the posts I've linked to.
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I don't think you have supported your case with sufficient up to date relevant information. I don't see why I should waste my time following links which have no value or interest to me. If you thought they were worth my consideration you would present them here and I will then explain why each particular link may be regarded with skepticism.
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"Harmful effects probably appear at sustained levels as low as 130 nmol/L."
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SHOW ME THE EVIDENCE?
I have shown you the reason's why
I believe 137.5nmol/l is associated with least chronic disease incidence
There are sufficient links on that chart to
All Cancers: Lappe JM, et al. Am J Clin Nutr. 2007;85:1586-91.
Breast: Garland CF, Gorham ED, Mohr SB, Grant WB, Garland FC.
Breast cancer risk according to serum 25-Hydroxyvitamin D: Meta-analysis of Dose-Response (abstract).American Association for Cancer Research Annual Meeting, 2008.
Reference serum 25(OH)D was 5 ng/ml. Garland, CF, et al. Amer Assoc Cancer Research Annual Mtg, April 2008,.
Colon: Gorham ED, et al. Am J Prev Med. 2007;32:210-6.
Diabetes: Hyppönen E, et al. Lancet 2001;358:1500-
Endometrium: Mohr SB, et al. Prev Med. 2007;45:323-4. Falls: Broe KE, et al. J Am Geriatr Soc. 2007;55:234-9.
Fractures: Bischoff-Ferrari HA, et al. JAMA. 2005;293:2257-64.
Heart Attack: Giovannucci et al. Arch Intern Med/Vol 168 (No 11) June 9, 2008.
Multiple Sclerosis: Munger KL, et al. JAMA. 2006;296:2832-8.
Non-Hodgkin’s Lymphoma: Purdue MP, et al.
Cancer Causes Control. 2007;18:989-99.
Ovary: Tworoger SS, et al. Cancer Epidemiol Biomarkers Prev. 2007;16:783-8. Renal: Mohr SB, et al. Int J Cancer. 2006;119:2705-9.
Rickets: Arnaud SB, 33% 54% 46%
Now if you have evidence to support your claim that 130nmol/l is dangerous where are your links to support your claim?