Quote:
Originally Posted by ItsTheWoo
...The evidence is not there that D is so hugely important....Maybe D helps a little. But the evidence is not there that it is significant as you seem to think it is...The evidence just isn't there to support your theory of D.
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I thought I would give you some of the evidence on which I based my theory of vitamin D's importance in obesity and insulin resistance.
Vit D_Obesity_Insulin
Treatment of Obesity With Vitamin D
This study is not yet open for patient recruitment.
Verified by University of Tromso September 2005
http://www.clinicaltrials.gov/ct/show/NCT00243256
Decreased bioavailability of vitamin D in obesity1,2,3
Jacobo Wortsman, Lois Y Matsuoka, Tai C Chen, Zhiren Lu and Michael F Holick
http://www.ajcn.org/cgi/content/full/72/3/690
Inadequate vitamin D status: Does it contribute to the disorders comprising syndrome ‘X’?
Boucher, B. J.1
http://<br />
http://www.ingentaco...53dc152d8667e07
Concentrations of Serum Vitamin D and the Metabolic Syndrome Among U.S. Adults
Earl S. Ford, MD, MPH1, Umed A. Ajani, MBBS, MPH1, Lisa C. McGuire, PHD1 and Simin Liu, MD, SCD2,3
http://<br />
http://care.diabetes.../full/28/5/1228
Hypovitaminosis D is associated with insulin resistance and ß cell dysfunction1,2,3
Ken C Chiu, Audrey Chu, Vay Liang W Go and Mohammed F Saad
http://<br />
http://www.ajcn.org/...stract/79/5/820
The effect of vitamin D3 on insulin secretion and peripheral insulin sensitivity in type 2 diabetic patients.
Borissova AM, Tankova T, Kirilov G, Dakovska L, Kovacheva R.
http://<br />
http://www.ncbi.nlm....l=pubmed_DocSum
Vitamin D endocrine system and the genetic susceptibility to diabetes, obesity and vascular disease. A review of evidence.
Reis AF, Hauache OM, Velho G.
http://<br />
http://www.ncbi.nlm....l=pubmed_docsum
Altered Calcium Homeostasis Is Correlated With Abnormalities of Fasting Serum Glucose, Insulin Resistance, and {beta}-Cell Function in the Newfoundland Population.
Sun G, Vasdev S, Martin GR, Gadag V, Zhang H
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
Regulation of multiple insulin-like growth factor binding protein genes by 1alpha,25-dihydroxyvitamin D3.
Matilainen M, Malinen M, Saavalainen K, Carlberg C.
http://<br />
http://www.ncbi.nlm....l=pubmed_docsum
Vitamin D and diabetes.
Mathieu C, Gysemans C, Giulietti A, Bouillon R.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_DocSum
Relationship between fasting serum glucose, age, body mass index and serum 25 hydroxyvitamin D in postmenopausal women.
Need AG, O'Loughlin PD, Horowitz M, Nordin BE.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_DocSum
Serum 25-Hydroxyvitamin D, Diabetes, and Ethnicity in the Third National Health and Nutrition Examination Survey
Robert Scragg, PHD1, MaryFran Sowers, PHD2 and Colin Bell, PHD3
http://care.diabetesjournals.org/cg...full/27/12/2813
Lack of effect of vitamin D administration during pregnancy and early life on diabetes incidence in the non-obese diabetic mouse.
Hawa MI, Valorani MG, Buckley LR, Beales PE, Afeltra A, Cacciapaglia F, Leslie RD, Pozzilli P.
http://www.ncbi.nlm.nih.gov/entrez/...Pager&DB=pubmed
Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in pancreatic islets.
Bland R, Markovic D, Hills CE, Hughes SV, Chan SL, Squires PE, Hewison M.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_DocSum
Oral administration of 1,25-dihydroxyvitamin D3 completely protects NOD mice from insulin-dependent diabetes mellitus.
Zella JB, McCary LC, DeLuca HF.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_DocSum
The vitamin D receptor gene variant and physical activity predicts fasting glucose levels in healthy young men.
Ortlepp JR, Metrikat J, Albrecht M, von Korff A, Hanrath P, Hoffmann R.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_DocSum
Identification of a Vitamin D response element in the human insulin receptor gene promoter.
Maestro B, Davila N, Carranza MC, Calle C.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_DocSum
Impaired insulin secretory capacity in mice lacking a functional vitamin D receptor.
Zeitz U, Weber K, Soegiarto DW, Wolf E, Balling R, Erben RG.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_DocSum
Adiposity in relation to vitamin D status and parathyroid hormone levels: a population-based study in older men and women.
Snijder MB, van Dam RM, Visser M, Deeg DJ, Dekker JM, Bouter LM, Seidell JC, Lips P.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
The relationship between obesity and serum 1,25-dihydroxy vitamin D concentrations in healthy adults.
Parikh SJ, Edelman M, Uwaifo GI, Freedman RJ, Semega-Janneh M, Reynolds J, Yanovski JA.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_DocSum
Body fat content and 25-hydroxyvitamin D levels in healthy women.
Arunabh S, Pollack S, Yeh J, Aloia JF.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_DocSum
Intakes of calcium and vitamin d predict body mass index in the population of Northern Norway.
Kamycheva E, Joakimsen RM, Jorde R.
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_DocSum
Vitamin D receptor gene polymorphisms are associated with obesity in type 2 diabetic subjects with early age of onset.
Ye WZ, Reis AF, Dubois-Laforgue D, Bellanne-Chantelot C, Timsit J, Velho G.
http://eje-online.org/cgi/reprint/145/2/181
Like I said, that's
some of the evidence. There's more.
And this sampling is
just on D's connection to obesity and insulin regulation, not on the myriad other instances where vitamin D status has significance for health.