Excessive use of the mouse and resting my wrists on the edge of my laptop can make my hands numb. The tablet is not much better; too much of the swiping motion causes pain and nerve pinching in my elbows. I have to take time outs, which is probably a good thing as too much couch-sitting causes leg tingling below my mid-thighs, right where they rest on the edge of the couch/chair seat. On days I stay off the computer I have no tingling/numbness anywhere.