I would second the recommendation to get a frame you can trust and a great bike shop. They can make wheels with more spokes which handles more weight. Also, I got pedal extenders which helps with the thighs putting the feet apart more.
I got a RANS Fusion and love, love it. It's a 'crank forward' frame (cross between conventional diamond frame and recumbent). In the comfort class but also fast and performance oriented.
Money quote from their forum when I was shopping: "the first bike that doesn't tell me how fat I am."
The frame geometry means your belly doesn't fight with your thighs, the gearing means you can move 300 pounds from a dead stop easily, the tires have the perfect balance between rolling resistance and performance...
It's rated to 275 pounds and on their forum a guy who was 330 pounds rode it no problem.
I'm selling this one at the moment but only because I want a girlie step through frame which RANS recently introduced.
RANS bikes
They also now sell a HammerTruck crank forward that is made for bike hauling and can handle 500 pounds. !
These bikes are not cheap is the downside. I saved up for mine and am very happy with it. If it doesn't sell I will be happy too, just, less able to ride in a skirt.