Excuse me for jumping into this thread, I seldom answer your questions because they are often on supplements I don’t know…MSM, 5htp, GBA, etc. In the 20 years here, I don’t know what you have tried before, but have you recently analyzed your diet to be sure your foods are supplying optimum nutrients? An intro article on nutrient density: https://optimisingnutrition.com/nut...101/#more-12093 After 10 years on a low carb diet, I found I have some micronutrient insufficiencies that only food, not supplements helped…maybe we get too complacent with the basics. Again, I don’t know what you have tried before to be sure your diet is nutrient dense….just an idea.