Thu, Sep-06-18, 10:38
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Senior Member
Posts: 1,596
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Plan: Carb reduction in general
Stats: 230/185/180
BF:
Progress: 90%
Location: Texas
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772929/
Quote:
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In vivo and in vitro studies have revealed that metformin has a direct antitumor effect, which may depress tumor proliferation and induce the apoptosis, autophagy and cell cycle arrest of tumor cells. The mechanism underpinning the antitumor effect of metformin has not been well established. Studies have demonstrated that reducing insulin and insulin-like growth factor levels in the peripheral blood circulation may lead to the inhibition of phosphoinositide 3-kinase/Akt/mechanistic target of rapamycin (mTOR) signaling or activation of AMP-activated protein kinase, which inhibits mTOR signaling, a process that may be associated with the antitumor effect of metformin.
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This is just an example of the first thing that popped up when I googled "metformin" with "cancer." There are some real effects going on with metformin in the anti-cancer and anti-aging fields, likely related to the above mechanisms. Would I take metformin just to slow aging without another medical reason to do so? Maybe not. But for those who need it anyway for other medical conditions, nice side effect benefit?
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