Hi, I have mctd(lupus,rheumotoid arthiritis and fibro) I had initially started with paxil however it made me gain weight, I also tried wellbutrin with the same results, I finally was put on Prozac (not really the 1st med for fibro) it was the one med on which I did not gain weight and on which I actually lost some. My rheumotologist said that each person reacts differently to each anti-depressant medication but unfortunately some make you gain weight or make it almost impossible to lose, something about serotonin (sorry, this was in German and I could not follow it all) I would talk to my doc and see what he suggests or what his experience is?? At this time I only take the German equivalent of Plaquenil(anti-malarial med) and an occasional diclofenec(NAISD). Well, lots of luck!!