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Old Sun, May-05-24, 13:57
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GRB5111 GRB5111 is online now
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Plan: Very LC, Higher Protein
Stats: 227/186/185 Male 6' 0"
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Progress: 98%
Location: Herndon, VA
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Quote:
Originally Posted by JEY100
Good summary of Type 2 Diabetes by Ted Naiman on Twitter today:
Quote:
The primary difference between someone with type 2 diabetes and someone without type 2 diabetes is mostly excess fat storage.

But what causes excess fat storage? Can you blame excess fat storage on either carbs or fat individually? Definitely not, and here’s why.

We have numerous studies on the dietary macronutrient ratios that optimally fatten either humans or other animals.

Optimal fat storage requires both carbs and fats. Diets that are low in protein (typically around 10%) with high levels of both fats and carbohydrates (often in the range of 40-60% for each) are particularly effective at promoting weight gain in both humans and animals. This macronutrient distribution mimics the composition of many forms of junk food and is utilized in research settings to induce obesity in animal models, commonly referred to as a "cafeteria diet."

The combination of high fat and high carbohydrate content is considered particularly obesogenic because it:

1. Increases palatability: High-fat and high-carb foods are generally more appealing and can lead to overeating.

2. Promotes fat storage: Excess calories from both carbs and fats are efficiently stored as body fat, more so than either macronutrient individually.

3. Disrupts energy balance: These diets can interfere with the normal regulation of hunger and satiety for reasons above, often leading to increased energy intake.

The majority of stored body fat comes from dietary fat, but this mechanistic view doesn’t mean that we can blame fat more than carbs for diabetes. Similarly, carbs raise blood glucose more than fat, but again this simplistic mechanistic viewpoint doesn’t mean that carbs can be blamed more than fat for type 2 diabetes.

Instead, you have to look at the big picture of what drives overeating. And all of the data points directly at a hyperpalatable low protein high energy density combination of carbs and fats together, with equal blame on both sides.

So it is really about a particular combination of low protein, high carb and high fat foods with lower than normal satiety per calorie.


Naiman has it right in that the combination of lower protein with high carbs and higher fats is often a deadly combination. Here's one of the researchers, Dr. Richard Johnson, who explains the actual metabolic mechanism very clearly in this interview:

https://www.youtube.com/watch?v=AMgBxyJvtx0

While it has the title of "Artificial Sweeteners," it's an interesting discussion about the Fructose Pathway and how glucose can trigger it under certain conditions. Whether you consume artificial sweeteners or not, there's enough here that potentially applies to everyone.
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