I just wanted to tell everyone I had trouble losing weight and then I was put on Metformin for my insulin resistance. Although the weight was coming off very well, I was sick to my stomach every day and it did not improve over time. I read about this with many people and just gave up hope and stopped the meds. I recently saw a new doctor who is an endocronologist and he said that a lot of people who switch to the brand name Glumetza do not suffer these side effects. I was skeptical but started on Glumetza. So far I have had no stomach issues at all. Just a tip for any of you feeling sick long term with Metformin. It's worth a shot.