My husband is diabetic. He was taking Glucophage 1000 mg daily. We started Protein Power May 5, 2003. He cut his Glucophage to 500 mg daily and his blood sugars have been running in the 90's to 112. He has been limiting his carbs to 30 a day. He has not had any problems with low blood sugar and he has already lost 12 pounds! However, as previously suggested, it would be a good idea for your husband to check with his doctor first. I hope this helps.