potassium and arterial calcification
https://www.sciencedaily.com/releas...71005102712.htm
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Always with the bananas and potassium... :lol: This was done in APOE deficient mice, this is a very common mouse model for atherosclerosis, developed with the assumption that dyslipidemia causes heart disease, because, cholesterol bad and stuff. APOE is a lipoprotein involved in the transport of fat into the lymph and into the brain. One thing usually not brought up--the pattern of transport of fat, large fluffy particles, small dense, high particle count, low particle count--since where goes fat, so go fat soluble vitamins, that changes the pattern of delivery of vitamin a,d,e,k. K and D especially are relevant to calcification of soft tissues. Vitamin D especially relates to cholesterol metabolism. What if the problem with APOE variants had little to do with cholesterol, and lots to do with fat soluble vitamins? No need to panic from this study that autophagy=atherosclerosis. APOE deficient mice that are calorie restricted have decreased atherosclerosis, also studies in humans who starved to death showed plaque regression, autophagy is a very broad term, this is just a case where autophagic processes were necessary to calcification under very specific conditions. https://insight.jci.org/articles/view/94920 Full study. No idea how this applies to humans, but keeping potassium intake from going too low seems low risk. Also sodium gets a bad rap, but most low carbers probably know by now that it has a role to play in preservation of body potassium, so I wonder what effect sodium has on APOE deficient mice? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568659/ Found this study. Not Apoe deficient, ldl receptor knockout, another model of dyslipidemia. Quote:
Not to jump to any conclusions, especially since all I've read of this study is pretty much the line I posted. :lol: But interesting. |
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This is a very reasonable assumption and along with Vitamin D, K2 could also be a complementary mechanism to move calcium to where it really belongs. Quote:
Right, that was my first reaction as I read the following quote: Quote:
The takeaway for me is that we are dealing with a very complex metabolism where controlled autophagy is a positive thing, and uncontrolled autophagy due to chemical shortfalls or distortions, like anything else, may result in an unhealthy outcome. Quote:
Here again, the mechanism of sodium resulting in somewhat higher systolic blood pressure may be protective. The following excerpt from the study's Discussion section: Quote:
One could posit that since dietary sodium has the effect of decreasing atherosclerotic lesions, the dynamic of higher systolic BP caused by sodium may also be a helpful mechanism. Lots to learn. |
Study reveals link between dietary potassium and vascular calcification
A need for bananas? Dietary potassium regulates calcification of arteries
by Jeff Hansen Bananas and avocados — foods that are rich in potassium — may help protect against pathogenic vascular calcification, also known as hardening of the arteries. University of Alabama at Birmingham researchers have shown, for the first time, that reduced dietary potassium promotes elevated aortic stiffness in a mouse model, as compared with normal-potassium-fed mice. Such arterial stiffness in humans is predictive of heart disease and death from heart disease, and it represents an important health problem for the nation as a whole. The UAB researchers also found that increased dietary potassium levels lessened vascular calcification and aortic stiffness. Furthermore, they unraveled the molecular mechanism underlying the effects of low or high dietary potassium. Such knowledge of how vascular smooth muscle cells in the arteries regulate vascular calcification emphasizes the need to consider dietary intake of potassium in the prevention of vascular complications of atherosclerosis. It also provides new targets for potential therapies to prevent or treat atherosclerotic vascular calcification and arterial stiffness. --snip snip-- Some low carb high K fruits/veggies Tomato carb=3.89g/100g, Potassium=237mg/100g, Sodium=5mg/100g Cucumber carb=3.63g/100g, Potassium=147mg/100g, Sodium=2mg/100g Tomatoes and cardiovascular health. https://www.ncbi.nlm.nih.gov/pubmed/12587984 Diet is believed to play a complex role in the development of cardiovascular disease, the leading cause of death in the Western world. Tomatoes, the second most produced and consumed vegetable nationwide, are a rich source of lycopene, beta-carotene, folate, potassium, vitamin C, flavonoids, and vitamin E. The processing of tomatoes may significantly affect the bioavailability of these nutrients. Homogenization, heat treatment, and the incorporation of oil in processed tomato products leads to increased lycopene bioavailability, while some of the same processes cause significant loss of other nutrients. Nutrient content is also affected by variety and maturity. Many of these nutrients may function individually, or in concert, to protect lipoproteins and vascular cells from oxidation, the most widely accepted theory for the genesis of atherosclerosis. This hypothesis has been supported by in vitro, limited in vivo, and many epidemiological studies that associate reduced cardiovascular risk with consumption of antioxidant-rich foods. Other cardioprotective functions provided by the nutrients in tomatoes may include the reduction of low-density lipoprotein (LDL) cholesterol, homocysteine, platelet aggregation, and blood pressure. Because tomatoes include several nutrients associated with theoretical or proven effects and are widely consumed year round, they may be considered a valuable component of a cardioprotective diet. Conclusion: slow cook tomato + oil/fat soup is the perfect food for both low carb and non low carb diets. This one get both K and lycopene bioavailability. |
Edited to confirm the two threads have been joined. Thanks to the Admin.
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And 2600mg in one teaspoon of French's NoSalt :)
https://www.fatsecret.com/calories-...frenchs/no-salt |
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Yes, and when I skip a meal, I am doing more than my waistline some good. I need more guacamole... |
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